Professor Dyfrig Hughes

Dyfrig Hughes graduated in pharmacy at Cardiff University before undertaking a PhD in cardiovascular pharmacology at the University of Liverpool (under the supervision of Dr Susan Coker). He subsequently trained in health economics (MSc, University of York), and was member of the Prescribing Research Group at the University of Liverpool (under the direction of Professor Tom Walley) until 2014.

Dyfrig is currently Professor of Pharmacoeconomics, co-director of the Centre for Health Economics and Medicines Evaluation at Bangor University and Director of Impact and Engagement. He is also academic lead for Pharmacy at the Betsi Cadwaladr University Health Board (covering North Wales), and is honorary professor at the Department of Molecular and Clinical Pharmacology, University of Liverpool.

Dyfrig leads the Pharmaceutical Economics, Pricing and Prescribing Research (PEPPER) group on research activities covering:

• Personalised medicine, including the evaluation of pharmacogenetic tests; development and assessment of interventions to improve medication adherence
• Trial-based economic evaluation, including drug treatments for cystic fibrosis, uveitis associated with juvenile idiopathic arthritis, type 1 and 2 diabetes, epilepsy, postpartum haemorrhage and haematological cancers
• Pharmaceutical policy, including analysis of variation in prescribing, societal perspectives on the funding of expensive treatments for rare diseases and cancers; assessment of new medicines for NHS Wales
• Methodological research, including integration of quantitative pharmacology and economic modelling; quantitative methods of benefit-risk assessment

His research has led to nearly 200 publications including in the prestigious medical journals New England Journal of Medicine, Lancet and BMJ; as well as the top-ranking discipline-specific journals, Clinical Pharmacology and Therapeutics, Value in Health, and Health Economics. One of his papers is listed as the highest cited article in the British Journal of Clinical Pharmacology. Dyfrig's papers have been cited 9,500 times, and resulting in an h-index of 47. Based on his recent publications, Dyfrig is ranked 2^th in the world (1^st in the UK) for expertise in pharmaceutical economics (according to Expertscape, October 2019). He has led and contributed to research totalling £56.6m in value.

Dyfrig has led the pharmacoeconomic activities of the All Wales Therapeutics and Toxicology Centre, contributing to over 200 substantive Health Technology Assessment reports informing medicines policy in Wales. He is a current member of the All Wales Medicines Strategy Group, and past member of the NICE technology appraisal committee. He chairs the pharmacogenomics test evaluation working group for the Genomics Programme in NHS England and NHS Improvement, and is also pharmacogenetics champion for the Royal Pharmaceutical Society. Dyfrig is also expert advisor to the Committee for Orphan Medicinal Products of the European Medicines Agency.

In 2016, Dyfrig was awarded Health and Care Research Wales Senior Research Leader (equivalent to NIHR Senior Investigator). He was inaugural president (and honorary member) of the International Society for Medication Adherence and is an elected fellow of: The Learned Society of Wales, The British Pharmacological Society, and the Faculty of the Royal Pharmaceutical Society. He is also an editorial board member of the journals PharmacoEconomics and Clinical Pharmacology & Therapeutics, and Executive Editorial Board member of the British Journal of Clinical Pharmacology and BMC Orphanet Journal of Rare Diseases.

Pharmaceutical economics and policy

Personalised medicine - economics of pharmacogenetics

Medication adherence

2024

• PublishedA model-based cost-utility analysis of an automated notification system for deteriorating patients on general wards
  Holmes, E., Hughes, D. & Subbe, C., 2 May 2024, In: PLoS ONE. 19, 5, p. e0301643 e0301643.
  Research output: Contribution to journal › Article › peer-review
• PublishedA proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials
  Totton, N., Waddingham, E., Owen, R., Julious, S., Hughes, D. & Cook, J., 22 Jun 2024, In: Trials. 25, 409.
  Research output: Contribution to journal › Article › peer-review
• PublishedDeveloping an alternative care pathway for emergency ambulance responses for adults with epilepsy: A Discrete Choice Experiment to understand which configuration service users prefer. Part of the COLLABORATE project
  Holmes, E., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., McKinlay, A., Dickson, J., Goodacre, S., Jackson, M., Foster, D., Hardman, K., Bell, S., Marson, A., Hughes, D. & Noble, A. J., Apr 2024, In: Seizure: European Journal of Epilepsy. 118, p. 28-37 10 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedDeveloping feasible person-centred care alternatives to emergency department responses for adults with epilepsy: a discrete choice analysis mixed methods study
  Noble, A. J., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., McKinlay, A., Dickson, J., Goodacre, S., Jackson, M., Morris, B., Hughes, D., Marson, T. & Holmes, E., Aug 2024, In: Health Services and Delivery Research (HS&DR). 12, 24
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomic analysis of treatments for children who do not achieve adequate asthma control when using low-dose inhaled corticosteroids
  Culeddu, G., Cividini, S., Sinha, I., Donegan, S., Maden, M., Rose, K., Fulton, O., Turner, S., Smith, C. T. & Hughes, D., 30 Jul 2024, In: Disease in Childhood. 109, suppl 1
  Research output: Contribution to journal › Conference article › peer-review
• E-pub ahead of printEvidence following conditional NICE technology appraisal recommendations: A critical analysis of methods, quality and risk of bias
  Pijeira Perez, Y. & Hughes, D., 9 Sept 2024, (E-pub ahead of print) In: Pharmacoeconomics.
  Research output: Contribution to journal › Article › peer-review
• PublishedPatient-led urate self-monitoring to improve clinical outcomes in people with gout: a feasibility study
  Michael, T. J. F., Wright, D. F. B., Chan, J. S., Coleshill, M. J., Aslani, P., Hughes, D., Day, R. O. & Stocker, S. L., Jul 2024, In: ACR Open Rheumatology. 6, 7, p. 403-411 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedService users' preferences and feasibility – which alternative care pathway for adult ambulance users achieves the optimal balance? Workshops for the COLLABORATE project
  Noble, A. J., Morris, B., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., Dickson, J., Goodacre, S., Jackson, M., Hughes, D., Marson, A. & Holmes, E., Apr 2024, In: Seizure: European Journal of Epilepsy. 118, p. 17-27 11 p.
  Research output: Contribution to journal › Article › peer-review
• E-pub ahead of printSupporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D pilot): results of a feasibility randomised trial
  SuMMiT-D Collaborative Group , 25 Jan 2024, (E-pub ahead of print) In: Pilot and Feasibility Studies. 10, 1, 15.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe clinical and cost-effectiveness of interventions for preventing continence issues resulting from birth trauma: a rapid review
  Anthony, B., Davies, J., Pisavadia, K., Roberts, S., Spencer, L. H., Gillen, E., Hounsome, J., Noyes, J., Hughes, D., Fitzsimmons, D., Edwards, R. T., Edwards, A., Cooper, A. & Lewis, R., 9 Sept 2024, MedRxiv.
  Research output: Working paper › Preprint
• PublishedThe costs and cost-effectiveness of different service models of palliatice care, focusing on end of life care: A rapid review
  Spencer, L., Anthony, B., Davies, J., Pisavadia, K., Gillen, E., Noyes, J., Fitzsimmons, D., Lewis, R., Cooper, A., Hughes, D., Edwards, R. T. & Edwards, A., 7 Mar 2024, MedRxiv, 118 p.
  Research output: Working paper › Preprint
• PublishedThe experiences and perspectives of people with gout on urate self-monitoring
  Michael, T. J. F., Chan, J. S., Hughes, S., Wright, D. F. B., Coleshill, M. J., Hughes, D., Day, R. O., Aslani, P. & Stocker, S. L., Jun 2024, In: Health Expectations. 27, 3, 9 p., e14071.
  Research output: Contribution to journal › Article › peer-review
• PublishedWe need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment
  Charlton, V., diStefano, M., Mitchell, P., Morrell, L., Rand, L., Badano, G., Baker, R., Calnan, M., Chalkidou, K., Culyer, A., Howden, D., Hughes, D., Lomas, J., Max, C., McCabe, C., O'Mahony, J. F., Paulden, M., Pemberton-Whiteley, Z., Rid, A., Scuffham, P., Sculpher, M., Shah, K., Weale, A. & Wester, G., Apr 2024, In: Health Economics, Policy and Law. 19, 2, p. 153-173
  Research output: Contribution to journal › Article › peer-review

2023

• PublishedA framework for understanding sources of bias in medication adherence research
  Sinnappah, K. A., Hughes, D., Stocker, S. L., Vrijens, B., Aronson, J. K. & Wright, D. F. B., Nov 2023, In: British Journal of Clinical Pharmacology. 89, 11, p. 3444-3453
  Research output: Contribution to journal › Article › peer-review
• PublishedA “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study
  Jorgensen, A., Waitt, C., Orrell, C., Cheng-Hock, T., Sekaggya-Wiltshire, C., Hughes, D., Allen, E., Okello, E., Tatz, G., Culeddu, G., Asiimwe, I. G., Semakula, J. R., Mouton, J. P., Cohen, K., Blockman, M., Lamorde, M. & Pirmohamed, M., 19 Jul 2023, In: Journal of Medical Internet Research. 12, e46710.
  Research output: Contribution to journal › Article › peer-review
• PublishedAppropriate design and reporting of superiority, equivalence and non-inferiority clinical trials incorporating a benefit risk assessment: the BRAINS study including expert workshop
  Totton, N., Julious, S., Coates, E., Hughes, D., Cook, J., Biggs, K., Hewitt, C., Day, S. & Cooke, A., Oct 2023, In: Health Technology Assessment. 27, 20, 86 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedBest step-up treatments for children with uncontrolled asthma: A systematic review and network meta-analysis of individual participant data
  Cividini, S., Sinha, I., Donegan, S., Maden, M., Rose, K., Fulton, O., Culeddu, G., Hughes, D., Turner, S. & Tudor-Smith, C., 21 Dec 2023, In: European Respiratory Journal. 62, 6, 2301011.
  Research output: Contribution to journal › Article › peer-review
• PublishedBetween- and within-individual sociodemographic and psychological determinants of PrEP adherence among men who have sex with men prescribed a daily PrEP regimen in Wales
  Gillespie, D., de Bruin, M., Hughes, D., Ma, R., Williams, A., Wood, F., Couzens, Z., Jones, A. T. & Hood, K., May 2023, In: AIDS and Behavior. 27, 5, p. 1564-1572 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedChanging Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: A protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy
  Al-Najjar, N., Bray, L., Carter, B., Collingwood, A., Cook, G., Crudgington, H., Dietz, K., Hardy, W., Hiscock, H., Hughes, D., Morris, C., Rouncefield-Swales , A., Saron, H., Spowart, C., Stibbs-Easton, L., Tudur Smith, C., Watson, V., Whittle, L., Wiggs, L., Wood, E., Gringas, P. & Pal, D. K., 10 Mar 2023, In: BMJ Open. 13, 3, e065769.
  Research output: Contribution to journal › Article › peer-review
• PublishedCost effectiveness analysis of treatments for children with uncontrolled asthma symptoms despite taking inhaled corticosteroids
  Culeddu, G., Sinha, I., Donegan, S., Maden, M., Cividini, S., Rose, K., Fulton, O., Turner, S., Tudor-Smith, C. & Hughes, D., 27 Oct 2023, In: European Respiratory Journal. 62 , Supplement 67, PA 523.
  Research output: Contribution to journal › Meeting Abstract › peer-review
• PublishedCosts of orphan medicinal products: longitudinal analysis of expenditure in Wales
  Pijeira Perez, Y., Wood, E. & Hughes, D., 1 Nov 2023, In: Orphanet Journal of Rare Diseases. 18, 1, 342.
  Research output: Contribution to journal › Article › peer-review
• PublishedEffectiveness of out-patient based acute heart failure care: A pilot randomised controlled trial
  Wong, K. Y. K., Hughes, D., Debski, M., Latt, N., Assaf, O., Abdelrahman, A., Taylor, R., Allgar, V., McNeill, L., Howard, S., Wong, S. Y. S., Jones, R., Cassidy, C. J., Seed, A., Galasko, G., Clark, A., Davis, G. K., Montasem, A., Lang, C. C., Kalra, P. R., Campbell, R., Lip, G. Y. H. & Cleland, J. G. F., Oct 2023, In: Acta Cardiologica. 78, 7, p. 828-837 10 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedHealth utilities and quality-adjusted life years for patients with amyotrophic lateral sclerosis receiving reldesemtiv or placebo in FORTITUDE-ALS
  Gebrehiwet, P., Meng, L., Saroccoa, P., Wei, J., Wolff, A. A., Butzner, M., Chio, A., Andrews, J. A., Genge, A., Hughes, D., Jackson, C. E., Lechtzin, N., Miller, T. M. & Shefner, J. M., 31 Mar 2023, In: Journal of Medical Economics. 26, 1, p. 488-493 6 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedMedication adherence research comes of age
  Wright, D. F. B., Sinnappah, K. A. & Hughes, D., Jul 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 1914-1917
  Research output: Contribution to journal › Editorial › peer-review
• PublishedMethodological considerations on estimating medication adherence from self-report, electronic monitoring, and electronic healthcare databases using the TEOS framework
  Dima, A. L., Allemann, S. S., Dunbar-Jacob, J., Hughes, D., Vrijens, B. & Wilson, I., Jul 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 1918-1927
  Research output: Contribution to journal › Article › peer-review
• PublishedPsychometric properties of an adapted stigma scale and experiences of stigma associated with HIV pre-exposure prophylaxis use among men who have sex with men: a mixed methods study
  Gillespie, D. & Hughes, D., Jul 2023, In: AIDS and Behavior. 27, 7, p. 2397-2410 14 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSuperiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial
  Marsden, J., Kelleher, M., Gilvarry, E., Mitcheson, L., Bisla, J., Cape, A., Cowden, F., Day, E., Dewhurst, J., Evans, R., Hardy, W., Hearn, A., Kelly, J., Lowry, N., McCusker, M., Murphy, C., Murray, R., Myton, T., Quarshie, S., Vanderwaal, R., Wareham, A., Hughes, D. & Hoare, Z., Dec 2023, In: eClinicalMedicine. 66, 23 p., 102331.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial
  Carter, B., Bray, L., Al-Najjar, N., Tort Piella, A., Smith, C. T., Spowart, C., Collingwood, A., Crudgington, H., Currier, J., Hughes, D., Wood, E., Martin, R., Morris, C., Roberts, D., Rouncefield-Swales , A., Sutherland, H., Watson, V., Cook, G., Wiggs, L., Gringas, P. & Pal, D., 6 Feb 2023, In: Trials. 24, 1, 83.
  Research output: Contribution to journal › Article › peer-review
• PublishedValue of improving patient safety: Health-economic considerations for Rapid Response Systems – a Rapid Review of the Literature and Expert Round Table
  Subbe, C., Hughes, D., Lewis, S., Holmes, E., Kalkman, C. J., So, R. K., Tranka, S. & Welch, J., 17 Apr 2023, In: BMJ Open. 13, 4, e065819.
  Research output: Contribution to journal › Article › peer-review
• PublishedWhat interventions or best practice are there to support people with Long COVID, or similar post-viral conditions or conditions characterised by fatigue, to return to normal activities: a rapid review
  Spencer, L., Hendry, A., Makanjuola, A., Anthony, B., Davies, J., Pisavadia, K., Hughes, D., Fitzsimmons, D., Wilkinson, C., Edwards, R. T., Lewis, R., Cooper, A. & Edwards, A., 28 Jan 2023, 34 p. (MedRxiv).
  Research output: Working paper › Preprint
• PublishedWhat is the effectiveness and cost-effectiveness of interventions in reducing the harms for children and young people who have been exposed to domestic violence or abuse: a rapid review.
  Spencer, L., Hendry, A., Makanjuola, A., Pisavadia, K., Davies, J., Albustami, M., Anthony, B., Wilkinson, C., Fitzsimmons, D., Hughes, D., Edwards, R. T., Lewis, R., Cooper, A. & Edwards, A., 10 May 2023, 79 p.
  Research output: Book/Report › Commissioned report

2022

• PublishedAdvanced therapy medicinal products: a comprehensive overview for pharmacy professionals
  McKenzie, C. A., Chappel, J., Guy, R. H., Hawksworth, G., Hughes, D. & Black, A., 12 Aug 2022, In: Pharmaceutical Journal.
  Research output: Contribution to journal › Article › peer-review
• PublishedAdverse drug reactions, multimorbidity and polypharmacy: A prospective analysis of one month of medical admissions
  Osanlou, R., Walker, L., Hughes, D., Burnside, G. & Pirmohamed, M., 4 Jul 2022, In: BMJ Open. 12, 7, e055551.
  Research output: Contribution to journal › Article › peer-review
• PublishedChoice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data
  Hill-McManus, D. & Hughes, D., Jun 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2782-2792 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedClinical interventions to improve adherence to urate-lowering therapy in patients with gout: a systematic review
  Sinnappah, K. A., Stocker, S. L., Chan, J. S., Hughes, D. A. & Wright, D. F. B., 25 Jun 2022, In: International Journal of Pharmacy Practice. 30, 3, p. 215-225 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedExperiences of men who have sex with men when initiating, implementing, and persisting with HIV pre-exposure prophylaxis
  Gillespie, D., Wood, F., Williams, A., Ma, R., de Bruin, M., Hughes, D., Jones, A. T., Couzens, Z. & Hood, K., Aug 2022, In: Health Expectations. 25, 4, p. 1332-1341 10 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedExtended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone
  Marsden, J., Kelleher, M., Hoare, Z., Hughes, D., Bisla, J., Cape, A., Cowden, F., Day, E., Dewhurst, J., Evans, R., Hearn, A., Kelly, J., Lowry, N., McCusker, M., Murphy, C., Murray, R., Myton, T., Quarshie, S., Scott, G., Turner, S., Vanderwaal, R., Wareham, A., Gilvarry, E. & Mitcheson, L., 19 Aug 2022, In: Trials. 23, 1, 697.
  Research output: Contribution to journal › Article › peer-review
• PublishedHealth utilities and costs for neuromyelitis optica spectrum disorder
  Hughes, D., Bourke, S., Jones, A., Bhatt, R., Huda, S., Mutch, K. & Jacob, A., 2022, In: Orphanet Journal of Rare Diseases. 17, 11 p., 159.
  Research output: Contribution to journal › Article › peer-review
• PublishedMethods for Extrapolating Survival Analyses for the Economic Evaluation of Advanced Therapy Medicinal Products
  Hardy, W. & Hughes, D., 16 Sept 2022, In: Human Gene Therapy. 33, 17-18, p. 845-856
  Research output: Contribution to journal › Article › peer-review
• PublishedNovel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug?
  Culeddu, G., Su, L., Chen, Y., Pereira, D. I. A., Powell, J. J. & Hughes, D., Mar 2022, In: British Journal of Clinical Pharmacology. 88, 3, p. 1347-1357 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedPrEP use, sexual behaviour, and PrEP adherence among men who have sex with men living in Wales prior to and during the COVID-19 pandemic
  Gillespie, D., Couzens, Z., de Bruin, M., Hughes, D., Jones, A., Ma, R., Williams, A., Wood, F. & Blee, K., Aug 2022, In: AIDS and Behavior. 26, 8, p. 2746-2757 12 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedRES00019. Wales COVID-19 Evidence Centre. A rapid evidence summary indicating the evidence of the inverse care law in social care in Wales and has this been exacerbated by the COVID-19 pandemic?
  Spencer, L., Hendry, A., Makanjuola, A., Hughes, D., Wilkinson, C., Pisavadia, K., Davies, J., Fitzsimmons, D. & Edwards, R. T., Feb 2022, Welsh Government. 33 p.
  Research output: Book/Report › Other report
• PublishedRES00038. Wales COVID-19 Evidence Centre. A rapid evidence summary of the cost impact of Long COVID on employment and caring responsibilities
  Spencer, L., Hendry, A., Davies, J., Pisavadia, K., Hughes, D. & Edwards, R. T., May 2022, Welsh Government. 18 p.
  Research output: Book/Report › Other report
• PublishedSupply-side cost-effectiveness thresholds: questions for evidence-based policy
  Sampson, C., Zamora, B., Watson, S., Cairns, J., Chalkidou, K., Cubi-Molla, P., Devlin, N., García-Lorenzo, B., Hughes, D., Leech, A. & Towse, A., Sept 2022, In: Applied Health Economics and Health Policy. 20, 5, p. 651-667
  Research output: Contribution to journal › Article › peer-review
• PublishedSupporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk: Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial
  Farmer, A. J., Jones, L., Newhouse, N., Kenning, C., Williams, N., Chi, Y., Bartlett, K., Plumpton, C., McSharry, J., Cholerton, R., Holmes, E., Robinson, S., Allen, J., Gudgin, B., Velardo, C., Rutter, H., Horne, R., Tarassenko, L., Williams, V., Locock, L., Rea, R., Yu, L.-M., Hughes, D., Bower, P. & French, D. P., 21 Feb 2022, In: JMIR Research Protocols. 11, 2, e32918.
  Research output: Contribution to journal › Article › peer-review
• PublishedWhat innovations can address inequalities experienced by women and girls due to the COVID-19 pandemic across the different areas of life/domains: work, health, living standards, personal security, participation and education? Report number – RR00027 (January 2022). Gender Inequalities: COVID-19 initiatives
  Spencer, L., Hartfiel, N., Hendry, A., Anthony, B., Makanjuola, A., Pisavadia, K., Davies, J., Bray, N., Hughes, D., Wilkinson, C., Fitzsimmons, D. & Edwards, R. T., 15 Jan 2022, Health and Care Research Wales.
  Research output: Book/Report › Commissioned report › peer-review
• PublishedWhat is the long-term impact of COVID-19 on the Health-Related Quality of Life of individuals with mild symptoms (or non-hospitalised): A rapid review
  Spencer, L., Hendry, A., Makanjuola, A., Davies, J., Pisavadia, K., Hughes, D., Fitzsimmons, D., Wilkinson, C., Edwards, R. T., Lewis, R., Cooper, A. & Edwards, A., 9 Sept 2022, Health and Care Research Wales, 47 p.
  Research output: Working paper › Preprint

2021

• PublishedA Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)
  Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J.-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., Jan 2021, In: Medicina. 57, 1, 17 p., 7.
  Research output: Contribution to journal › Article › peer-review
• PublishedA Systematic Review of Economic Evaluations of Advanced Therapy Medicinal Products
  Lloyd Williams, H. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2428-2443 16 p.
  Research output: Contribution to journal › Review article › peer-review
• PublishedAcceptability of generic versus innovator oral medicines: not only a matter of taste
  Tuleu, C., Hughes, D., Clapham, D., Vallet, T. & Ruiz, F., Feb 2021, In: Drug Discovery Today. 26, 2, p. 329-343
  Research output: Contribution to journal › Article › peer-review
• PublishedCombining model-based clinical trial simulation, pharmacoeconomics and value of information to optimize trial design
  Hill-McManus, D. & Hughes, D., Jan 2021, In: CPT: Pharmacometrics & Systems Pharmacology . 10, 1, p. 75-83 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedContent of Health Economics Analysis Plans (HEAPs) for trial-based economic evaluations: expert Delphi consensus survey
  Thorn, J., Davies, C. F., Brookes, S., Noble, S., Dritsaki, M., Gray, E., Hughes, D., Mihaylova, B., Petrou, S., Ridyard, C., Sach, T., Wilson, E., Wordsworth, S. & Hollingworth, W., 1 Apr 2021, In: Value in Health. 24, 4, p. 539-547 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-Effectiveness Analysis of Mycophenolate Mofetil Versus Cyclophosphamide for Remission Induction in Childhood Polyarteritis Nodosa
  Culeddu, G., Brogan, P. A. & Hughes, D., 2021.
  Research output: Contribution to conference › Other › peer-review
• PublishedCost-effectiveness of home versus hospital management of children at onset of Type 1 Diabetes: The DECIDE randomised controlled trial
  McCarroll, Z., Townson, J., Pickles, T., Gregory, J. W., Playle, R., Robling, M. & Hughes, D., 19 May 2021, In: BMJ Open. 11, 5, e043523.
  Research output: Contribution to journal › Article › peer-review
• PublishedEarly impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales
  Gillespie, D., Knapper, C., Hughes, D., Couzen, Z., Wood, F., de Bruin, M., Ma, R., Jones, A. T., Williams, A. & Hood, K., 17 Feb 2021, In: Sexually transmitted infections. 97, 2, p. 85-87 3 p., 054598.
  Research output: Contribution to journal › Article › peer-review
• PublishedEstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): Protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD)
  Cividini, S., Sinha, I., Donegan, S., Maden, M., Culeddu, G., Rose, K., Fulton, O., Hughes, D., Turner, S. & Smith, C. T., 5 Feb 2021, In: BMJ Open. 11, e040528.
  Research output: Contribution to journal › Article › peer-review
• PublishedHave infection control and prevention measures resulted in any adverse outcomes for care home and domiciliary care residents and staff? Report number: RR_00018 (November 2021)
  Spencer, L., Hartfiel, N., Hendry, A., Anthony, B., Makanjuola, A., Bray, N., Hughes, D., Wilkinson, C., Fitzsimmons, D. & Edwards, R. T., 1 Nov 2021, 36 p.
  Research output: Book/Report › Other report › peer-review
• PublishedIs there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series
  Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., Livingston, M., Javed, A., Moreno, G. Y. C., Watt, T., Stedman, M. & Hughes, D., 28 Dec 2021, In: International Journal of Clinical Practice. 75, 12, e14967.
  Research output: Contribution to journal › Article › peer-review
• PublishedLamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs
  Marson, A. G., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P. R., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., Dec 2021, In: Health Technology Assessment. 25, 75, 162 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedLinked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development
  Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 49-63
  Research output: Contribution to journal › Article › peer-review
• PublishedLiothyronine for hypothyroidism: A candidate for disinvestment or in need of further research? A value of information analysis
  Hughes, D., Skiadas, K., Fitzsimmons, D., Anderson, P. & Heald, A., 3 Dec 2021, In: BMJ Open. 11, 12, e051702.
  Research output: Contribution to journal › Article › peer-review
• PublishedManaging Access to Advanced Therapy Medicinal Products: Challenges for NHS Wales
  Champion, A. R., Lewis, S., Davies, S. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2444-2449
  Research output: Contribution to journal › Article › peer-review
• PublishedMechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial
  Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., Sharma, M., Frank, B., Bassett, P., Marshall, A. & Goebel, A., 6 Nov 2021, In: Journal of Translational Medicine. 19, 1, 458.
  Research output: Contribution to journal › Article › peer-review
• PublishedMicrodiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT
  Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Bostock, J., Hay, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. & Williamson, P. R., Apr 2021, In: Health Technology Assessment. 25, 24, 86 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedMycophenolate Mofetil Versus Cyclophosphamide for Remission Induction in Childhood Polyarteritis Nodosa: An Open-Label, Randomized, Bayesian Noninferiority Trial
  Brogan, P. A., Arch, B., Hickey, H., Anton, J., Iglesias, E., Baildam, E., Mahmood, K., Cleary, G., Moraitis, E., Papadopoulou, C., Beresford, M. W., Riley, P., Demir, S., Ozen, S., Culeddu, G., Hughes, D., Dolezalova, P., Hampson, L., Whitehead, J., Jayne, D., Ruperto, N., Tudor-Smith, C. & Eleftheriou, D., Sept 2021, In: Arthritis and Rheumatology. 73, 9, p. 1673-1682
  Research output: Contribution to journal › Article › peer-review
• PublishedPerceptions of European ME/CFS experts concerning knowledge and understanding of ME/CFS among primary care physicians in Europe: A report from the European ME/CFS Research Network (EUROMENE)
  Cullinan, J., Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., de Korwin, J.-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., 26 Feb 2021, In: Medicina. 57, 3, 208.
  Research output: Contribution to journal › Article › peer-review
• PublishedPharmacogenomics spotlight commentary: From the United Kingdom to global populations
  Magavern, E. F., Daly, A. K., Gilchrist, A. & Hughes, D., Dec 2021, In: British Journal of Clinical Pharmacology. 87, 12, p. 4546-4548 3 p., 14917.
  Research output: Contribution to journal › Comment/debate › peer-review
• PublishedPlasma Methylmalonic Acid Concentration in Folic Acid–Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial
  Carter, B., Zenasni, Z., Moat, S. J., Hudson, P. R., Russell, I. T., McCaddon, A., Whitaker, R., Pink, J., Roberts, S., Wilkinson, C., Hughes, D., Betson, E., Carr, D., Jorgenson, A., Pirmohamed, M., Williams, N., Lewis, H., Lloyd, K., Sylvesture, Y. & Tranter, R., Dec 2021, In: Journal of Nutrition. 151, 12, p. 3738-3745 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedQuantitative evidence synthesis methods for the assessment of the effectiveness of treatment sequences for clinical and economic decision-making: a review and taxonomy of simplifying assumptions
  Lewis, R., Hughes, D., Sutton, A. & Wilkinson, C., Jan 2021, In: PharmacoEconomics. 39, 1, p. 25-61 37 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSurgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation
  Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson , P. J., Hughes, D., Marson, A. G. & Williamson, P., 1 May 2021, In: The Lancet Rheumatology. 3, 5, p. e347-e356
  Research output: Contribution to journal › Article › peer-review
• PublishedTEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources
  Dima, A. L., Allemann, S. S., Dunbar-Jacobs, J., Hughes, D., Vrijens, B. & Wilson, I., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2521-2533
  Research output: Contribution to journal › Article › peer-review
• PublishedThe SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
  Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G. A., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., 10 Apr 2021, In: The Lancet. 397, 10282, p. 1363-1374
  Research output: Contribution to journal › Article › peer-review
• PublishedThe SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
  Marson, A., Burnside, G., Appleton, R., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G. A., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., 10 Apr 2021, In: The Lancet. 397, 10282, p. 1375-1386
  Research output: Contribution to journal › Article › peer-review
• PublishedThe role of prevention in reducing the economic impact of ME/CFS in Europe: A report from the socioeconomics working group of the European Network on ME/CFS (EUROMENE).
  Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J.-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., 16 Apr 2021, In: Medicina. 57, 4, 388.
  Research output: Contribution to journal › Article › peer-review
• PublishedUsing Routinely Recorded Data in a UK RCT: A Comparison to Standard Prospective Data Collection Methods
  Powell, G., Bonnett, L., Tudor-Smith, C., Hughes, D., Williamson, P. R. & Marson, A. G., 5 Jul 2021, In: Trials. 22, 1, 429.
  Research output: Contribution to journal › Article › peer-review
• PublishedUtilising Benefit-Risk Assessments within Clinical Trials – A Protocol for the BRAINS project
  Totton, N., Julious, S., Hughes, D., Cook, J., Biggs, K., Coates, L., Cook, A., Hewitt, C. & Day, S., 19 Jan 2021, In: Trials. 22, 68.
  Research output: Contribution to journal › Article › peer-review
• PublishedWhat should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics
  Albassam, A. & Hughes, D., Feb 2021, In: European Journal of Clinical Pharmacology. 77, 2, p. 251-260 10 p.
  Research output: Contribution to journal › Article › peer-review

2020

• PublishedAcute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam
  Hughes, D., Nov 2020, In: British Journal of Pharmacology. 177, 21, p. 4975-4989 15 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedCarer administration of as-needed sub-cutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT
  Poolman, M., Roberts, J., Wright, S., Hendry, A., Goulden, N., Holmes, E., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., Hiscock, J., Hughes, D., O'Connor, J., Foster, B., Reymond, L., Healy, S., Lewis, P., Wee, B., Johnstone, R. P., Roberts, R., Parkinson, A., Roberts, S. & Wilkinson, C., 2 Jun 2020, In: Health Technology Assessment. 24, 25, 150 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedImpact of relaxing Covid-19 social distancing measures on rural North Wales: a simulation analysis
  Hughes, R. P. & Hughes, D., 14 Dec 2020, In: Frontiers in Public Health. 8, 562473.
  Research output: Contribution to journal › Article › peer-review
• PublishedManagement of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority
  Hughes, D., Livingston, M. & Heald, A., Sept 2020, In: Experimental and Clinical Endocrinology & Diabetes . 128, 9, p. 596-598
  Research output: Contribution to journal › Letter › peer-review
• PublishedMedication adherence – key considerations for clinical pharmacologists
  Hughes, D., Apr 2020, In: British Journal of Clinical Pharmacology. 86, 4, p. 628-629 2 p.
  Research output: Contribution to journal › Editorial › peer-review
• PublishedSeizure First Aid Training For people with Epilepsy (SAFE) frequently attending emergency departments and their significant others: results of a UK multi-centre randomised controlled pilot trial
  Noble, A. J., Snape, D., Nevitt, S., Holmes, E., Morgan, M., Smith, C. T., Hughes, D., Buchanan, M., McVicar, J., MacCallum, E., Goodacre, S., Rinsdale, L. & Marson, A. G., 16 Apr 2020, In: BMJ Open. 10, 4, e035516.
  Research output: Contribution to journal › Article › peer-review
• PublishedSilver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT
  Mallucci, C. L., Jenkinson, M., Conroy, E. J., Hartley, J. C., Brown, M., Moitt, T., Dalton, J., Kearns, T., Griffiths, M. J., Culeddu, G., Solomon, T., Hughes, D. & Gamble, C., 2 Apr 2020, In: Health Technology Assessment. 24, 17, 114 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedStudy protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II)
  Balabanova, S., Taylor, C., Sills, G., Burnside, G., Plumpton, C., Smith, P., Appleton, R., Leach, J. P., Johnson, M., Baker, G. A., Pirmohamed, M., Hughes, D., Williamson, P., Tudor-Smith, C. & Marson, A. G., 26 Aug 2020, In: BMJ Open. 10, 8, e040635.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)
  Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J.-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., 7 Apr 2020, In: Healthcare. 8, 2, 88.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe new and non-transparent Cancer Drugs Fund
  Wood, E. & Hughes, D., Jan 2020, In: PharmacoEconomics. 38, 1, p. 1-4
  Research output: Contribution to journal › Article › peer-review

2019

• PublishedA Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System
  McIntyre, K. M., Bolton, F. J., Christley, R. M., Cleary, P., Deja, E., Durie, A. E., Diggle, P. J., Hughes, D., de Lusignan, S., Orton, L., Radford, A. D., Elliot, A., Smith, G. E., Snape, D. A., Stanistreet, D., Vivancos, R., Winstanley, C. & O'Brien, S. J., 26 Sept 2019, In: JMIR Research Protocols. 8, 9, p. e13941 10 p., e13941.
  Research output: Contribution to journal › Article › peer-review
• PublishedAdalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT
  Ramanan, A. V., Dick, A. D., Jones, A. P., Hughes, D., McKay, A., Rosala_Hanna, A., Williamson, P. R., Hardwick, B., Hickey, H., Rainford, N., Kolamunnage-Dona, R., Culeddu, G., Plumpton, C., Wood, E., Compeyrot-Lacassagne, S., Woo, P., Eldesten, C. & Beresford, M. W., 10 Apr 2019, In: Health Technology Assessment. 23, 15, p. 1-174 174 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedAntibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multi-centre, single-blinded, randomised trial and economic evaluation
  Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Dalton, J., Kearns, T., Moitt, T., Griffiths, M. J., Culeddu, G., Solomon, T., Hughes, D. & Gamble, C., 26 Oct 2019, In: The Lancet. 394, 10208, p. 1530-1539 10 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedCARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial
  Poolman, M., Roberts, J., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., Hiscock, J., Hughes, D., Foster, B., O'Connor, J., Reymond, L., Healy, S., Roberts, R., Wee, B., Lewis, P., Johnstone, R., Roberts, S., Holmes, E., Wright, S., Hendry, A. & Wilkinson, C., 7 Feb 2019, In: Trials. 20, 1, 16 p., 105.
  Research output: Contribution to journal › Article › peer-review
• PublishedChallenges for economic evaluation of strategies to contain antimicrobial resistance
  Holmes, E. & Hughes, D., 27 Sept 2019, In: Antibiotics. 8, 4, 8 p., 166.
  Research output: Contribution to journal › Comment/debate › peer-review
• PublishedCommunity views on factors affecting medicines resource allocation: Cross-sectional survey of 3080 adults in Australia
  Chim, L., Salkeld, G., Kelly, P., Lipworth, W., Hughes, D. & Stockler, M., 2019, In: Australian Health Review . 43, 3, p. 254-260
  Research output: Contribution to journal › Article › peer-review
• PublishedContinuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation
  Blair, J. C., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., Didi, M., Annan, F., Gregory, J. W., Hughes, D. A. & Gamble, C., 3 Apr 2019, In: British Medical Journal. 365, p. l1226 l1226.
  Research output: Contribution to journal › Article › peer-review
• PublishedCore Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus
  Crudgington, H., Rogers, M., Bray, L., Carter, B., Currier, J., Gibbon, F., Hughes, D., Lyle, S., Roberts, D., Smith, C. T., Gringras, P., Pal, D. & Morris, C., May 2019, In: Epilepsia. 60, 5, p. 857-871
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis
  Hughes, D. A., Culeddu, G., Plumpton, C. O., Wood, E., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot Lacassagne, S., Hardwick, B., Hickey, H., Woo, P., Beresford, M. W. & Ramanan, A. V., Mar 2019, In: Ophthalmology. 126, 3, p. 415-424
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis: Authors’ reply.
  Hughes, D., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Beresford, M. W. & Ramanan, A. V., Mar 2019, In: Ophthalmology. 126, 3, p. e24-e25
  Research output: Contribution to journal › Letter › peer-review
• PublishedCost-effectiveness of panel tests for multiple pharmacogenes associated with adverse drug reactions: An evaluation framework
  Plumpton, C., Pirmohamed, M. & Hughes, D., Jun 2019, In: Clinical Pharmacology and Therapeutics. 105, 6, p. 1429-1438
  Research output: Contribution to journal › Article › peer-review
• PublishedDeveloping patient-centred, feasible alternative care for adult emergency department users with epilepsy: Protocol for the mixed-methods observational ‘Collaborate’ project.
  Noble, A. J., Mathieson, A., Ridsdale, L., Holmes, E., Morgan, M., McKinlay, A., Dickson, J., Jackson, M., Hughes, D., Goodacre, S. & Marson, A. G., 2 Nov 2019, In: BMJ Open. 9, 11, e031696.
  Research output: Contribution to journal › Article › peer-review
• PublishedEvidence to support inclusion of pharmacogenetic biomarkers in randomised controlled trials
  Johnson, D., Jorgensen, A., Hughes, D. & Pirmohamed, M., 1 Sept 2019, In: Journal of Personalized Medicine. 9, 3, 19 p., 42.
  Research output: Contribution to journal › Review article › peer-review
• PublishedHealth utilities and costs for Motor Neurone Disease
  Moore, A., Young, C. A. & Hughes, D., Nov 2019, In: Value in Health. 22, 11, p. 1257-1265
  Research output: Contribution to journal › Article › peer-review
• PublishedImproving Medication Adherence Research Reporting: European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline
  de Geest, S., Zullig, L., Dunbar-Jacobs, J., Hughes, D., Wilson, I. & Vrijens, B., Jun 2019, In: Journal of Cardiovascular Nursing. 34, 3, p. 199-200
  Research output: Contribution to journal › Editorial › peer-review
• PublishedImproving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE)
  de Geest, S., Zullig, L. L., Dunbar-Jacob, J., Hughes, D., Wilson, I. & Vrijens, B., 1 Apr 2019, In: European Journal of Cardiovascular Nursing. 18, 4, p. 258-259 2 p.
  Research output: Contribution to journal › Editorial › peer-review
• PublishedIntegration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout
  Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sept 2019, In: Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660
  Research output: Contribution to journal › Article › peer-review
• PublishedMedicines Shortages in the United Kingdom
  Hughes, D., Oct 2019, In: Clinical Pharmacology and Therapeutics. 106, 4, p. 712
  Research output: Contribution to journal › Letter › peer-review
• PublishedPatient-focused drug development methods for benefit-risk assessments: A case study using discrete choice experiment for antiepileptic drugs
  Holmes, E. A. F., Plumpton, C., Baker, G. A., Jacoby, A., Ring, A., Williamson, P., Marson, A. & Hughes, D. A., Mar 2019, In: Clinical Pharmacology and Therapeutics. 105, 3, p. 672-683 12 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedStatistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Non-adherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers
  Alshreef, A., Latimer, N., Tappenden, P., Wong, R., Hughes, D., Fotheringham, J. & Dixon, S., Nov 2019, In: Medical Decision Making. 39, 8, p. 910-925 16 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSupporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol
  Farmer, A. J., Allen, J., Bartlett, K., Bower, P., Chi, Y., French, D. P., Gudgin, B., Holmes, E., Horne, R., Hughes, D., Kenning, C., Locock, L., McSharry, J., Miles, L., Newhouse, N., Rea, R., Riga, J., Tarassenko, L., Velardo, C., Williams, N., Williams, V. & Yu, L.-M., 29 Dec 2019, In: BMJ Open. 9, 12, e033504.
  Research output: Contribution to journal › Article › peer-review
• PublishedSystematic Review: Outcomes and adverse events from randomised trials in Crohn's disease
  Catt, H., Hughes, D., Kirkham, J. K. & Bodger, K., Apr 2019, In: Alimentary Pharmacology and Therapeutics. 49, 8, p. 978-996 19 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedValue assessment and quantitative benefit-risk modelling of biosimilar infliximab for Crohn’s disease
  Catt, H., Bodger, K., Hughes, D. & Kirkham, J. J., Dec 2019, In: PharmacoEconomics. 37, 12, p. 1509-1523 15 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedWhat really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK
  Ring, A., Jacoby, A., Baker, G., Holmes, E., Hughes, D., Kierans, C. & Marson, A., Jun 2019, In: Epilepsy and Behavior. 95, p. 181-191
  Research output: Contribution to journal › Article › peer-review

2018

• PublishedContinuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT
  Blair, J., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., Didi, M., Annan, F., Gregory, J. W., Hughes, D. & Gamble, C., Aug 2018, In: Health Technology Assessment. 22, 42, p. 1-112 112 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedCore items for a standardized resource-use measure (ISRUM): expert Delphi consensus survey
  Thom, J., Brookes, S. T., Ridyard, C., Riley, R., Hughes, D., Wordsworth, S., Noble, S., Thornton, G. & Hollingworth, W., Jun 2018, In: Value in Health. 21, 6, p. 640-649
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care
  Holmes, E., Harris, S. D., Hughes, A., Craine, N. & Hughes, D., 7 Dec 2018, In: Antibiotics. 7, 4, 19 p., 106.
  Research output: Contribution to journal › Article › peer-review
• PublishedDo guidelines for treating chest disease in children use Cochrane reviews effectively? A systematic review
  Prayle, A., Cox, T., Smith, S. J., Rycroft-Malone, J., Thomas, K. S., Hughes, D. & Smyth, A. R., Jul 2018, In: Thorax. 73, 7, p. 670-673
  Research output: Contribution to journal › Letter › peer-review
• PublishedESPACOMP Medication Adherence Reporting Guideline (EMERGE)
  De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Helmy, R., Hughes, D., Wilson, I. & Vrijens, B., 3 Jul 2018, In: Annals of Internal Medicine. 169, 1, p. 30-35
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomics of pharmacogenetic guided treatments: Underwhelming or overstated?
  Hughes, D., May 2018, In: Clinical Pharmacology and Therapeutics. 103, 5, p. 749-751
  Research output: Contribution to journal › Article › peer-review
• PublishedImpact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model
  Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Dec 2018, In: Value in Health. 21, 12, p. 1373-1381
  Research output: Contribution to journal › Article › peer-review
• PublishedImpact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout
  Hill McManus, D., Soto, E., Marshall, S., Lane, S. & Hughes, D., Jan 2018, In: British Journal of Clinical Pharmacology. 84, 1, p. 142-152
  Research output: Contribution to journal › Article › peer-review
• PublishedImpact on the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales
  Alam, M. F., Cohen, D., Dunstan, F., Hughes, D. & Routledge, P. A., Jan 2018, In: Health Economics. 27, 1, p. 236-243
  Research output: Contribution to journal › Article › peer-review
• PublishedInnovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care
  Swift, B., Jain, L., White, C., Chandrasekaran, V., Bhandari, A., Hughes, D. & Jadhav, P., Sept 2018, In: Clinical and Translational Science. 11, 5, p. 450-460 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedLessons learnt from a discontinued randomised controlled trial: Adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)
  Williams, N., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D., Wood, E., Foster, N. E., Walsh, D. A., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S. & Wilkinson, C., 31 Jul 2018, In: Trials. 19, 408.
  Research output: Contribution to journal › Article › peer-review
• PublishedLetter to the Editor. Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma
  Jenkinson, M., Weber, D., Haylock, B., Sherratt, F., Young, B., Weller, M., Bulbeck, H., Culeddu, G., Hughes, D., Brain, A., Das, K., Preusser, M., Francis, P. & Gamble, C., 17 Aug 2018, In: Journal of Neurology, Neurosurgery and Psychiatry.
  Research output: Contribution to journal › Letter › peer-review
• PublishedMapping ALSFRS-R and ALSUI to EQ-5D in patients with motor neurone disease
  Moore, A., Young, C. A. & Hughes, D., Nov 2018, In: Value in Health. 21, 11, p. 1322-1329
  Research output: Contribution to journal › Article › peer-review
• PublishedNew Medicines in Wales: The All Wales Medicines Strategy Group (AWMSG) Appraisal Process and Outcomes
  Varnava, A., Samuels, K., Hughes, D. & Routledge, P. A., May 2018, In: Pharmacoeconomics. 36, 5, p. 613-624 12 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedRare disease prevention and treatment: The need for a level playing field
  Hughes, D. & Plumpton, C., Feb 2018, In: Pharmacogenomics. 19, 3, p. 243-247
  Research output: Contribution to journal › Article › peer-review
• PublishedSocietal preferences for funding orphan drugs in the United Kingdom: An application of person trade off and discrete choice experiment methods
  Bourke, S. M., Plumpton, C. & Hughes, D., 9 May 2018, In: Value in Health. 21, 5, p. 538-546
  Research output: Contribution to journal › Article › peer-review

2017

• PublishedAdalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis
  Ramanan, A. V., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot-Lacassagne, S., Hardwick, B., Hickey, H., Hughes, D., Woo, P., Benton, D., Edelsten, C. & Beresford, M. W., 27 Apr 2017, In: New England Journal of Medicine. 376, 17, p. 1637-1646
  Research output: Contribution to journal › Article › peer-review
• PublishedAffordable orphan drugs: A role for not-for-profit organisations
  Davies, E. H., Fulton, E., Brook, D. & Hughes, D., Jul 2017, In: British Journal of Clinical Pharmacology. 83, 7, p. 1595-1601
  Research output: Contribution to journal › Article › peer-review
• PublishedCarer-administration of as-needed sub-cutaneous medication for breakthrough symptoms in homebased dying patients: a UK study (CARIAD)
  Wilkinson, C., Poolman, M., Roberts, J., Wee, B., Hiscock, J., Hughes, D., Nelson, A., Perkins, P., Johnstone, R. P., Reymond, E., Foster, B., O'Connor, J., Jones, S., Hoare, Z., Roberts, R., Byrne, A., Healy, S. & Lewis, P., 1 Sept 2017.
  Research output: Contribution to conference › Poster › peer-review
• PublishedComparison of regression methods for the cost effectiveness analysis of clinical trials with a small population size: the sycamore and folated trials
  Culeddu, G., Hughes, D. & Welton, N., 10 Jul 2017.
  Research output: Contribution to conference › Poster › peer-review
• PublishedContinuous Subcutaneous Infusion Versus Multiple Dose Injection of Insulin For Newly-Diagnosed T1D Paediatric Patients: A Cost-Utility Analysis
  Ridyard, C., Blair, J. & Hughes, D., 20 Oct 2017, In: Value in Health. 20, 9, p. A582
  Research output: Contribution to journal › Article › peer-review
• PublishedContinuous subcutaneous insulin infusion compated to multiple daily injection regimens in children and yung people at diagnosis of type 1 diabetes: A pragmatic randomised controlled trial and economic evaluation (scipi trial)
  Blair, J., Mckay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., Didi, M., Annan, F., John, G., Hughes, D. & Gamble, C., Sept 2017, p. 22-23.
  Research output: Contribution to conference › Abstract › peer-review
• PublishedCore items for a standardised resource-use measure (ISRUM):expert Delphi consensus survey
  Thorn, J., Ridyard, C., Riley, R., Brookes, S., Hughes, D., Wordsworth, S., Noble, S., Thornton, G. & Hollingworth, W., 7 May 2017, p. P265. 1 p.
  Research output: Contribution to conference › Poster › peer-review
• PublishedCost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout
  Plumpton, C., Alfirevic, A., Pirmohamed, M. & Hughes, D., 1 Oct 2017, In: Rheumatology. 56, 10, p. 1729-1739
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness of HLA-B*15:02 screening in Malaysia
  Plumpton, C. & Hughes, D., Oct 2017, In: British Journal of Dermatology. 177, 4, p. 904-905
  Research output: Contribution to journal › Comment/debate
• PublishedCost-effectiveness of paediatric central venous catheters in the UK: A secondary publication from the CATCH clinical trial
  Ridyard, C., Plumpton, C., Gilbert, R. E. & Hughes, D., 19 Sept 2017, In: Frontiers in Pharmacology. 8, 644.
  Research output: Contribution to journal › Article › peer-review
• PublishedDecision analytic modelling methods for the assessing the effectiveness of treatment sequences for clinical and economic decision making: a methodological review
  Lewis, R., Hughes, D. & Wilkinson, C., 30 Nov 2017, In: Value in Health. 20, 9, p. A748 1 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomic Studies in Motor Neurone Disease: A Systematic Methodological Review
  Moore, A., Young, C. A. & Hughes, D., Apr 2017, In: Pharmacoeconomics. 35, 4, p. 397-413
  Research output: Contribution to journal › Article › peer-review
• PublishedHealth economics analysis plans: the current state of play
  Thorn, J., Ridyard, C., Hughes, D., Wordsworth, S., Mihaylova, B., Noble, S. & Hollingworth, W., 7 May 2017, p. P144. 1 p.
  Research output: Contribution to conference › Poster › peer-review
• PublishedPatient preferences for outcomes in clinical trials: implications for medicines optimization
  Holmes, E., Marson, A. G. & Hughes, D., 8 May 2017, In: Trials. 18 (Suppl 1), O18, p. 192 1 p.
  Research output: Contribution to journal › Meeting Abstract › peer-review
• PublishedPatient-level information and costing systems (PLICS) as a source of routinely collected cost data for trial-based economic evaluations
  Ridyard, C. & Hughes, D., 7 May 2017, p. P141. 1 p.
  Research output: Contribution to conference › Poster › peer-review
• PublishedPatterns In Working Days Lost By Parents Of Children Newly-Diagnosed With Type 1 Diabetes (T1D)
  Ridyard, C., Blair, J. & Hughes, D., 20 Oct 2017, In: Value in Health. 20, 9, p. A590
  Research output: Contribution to journal › Article › peer-review
• PublishedPump-Downloaded Insulin Usage For The First 12 Months In A Cohort of Children Newly-Diagnosed With Type 1 Diabetes (T1D)
  Ridyard, C., Blair, J. & Hughes, D., Nov 2017, In: Value in Health. 20, 9, p. A481 - A482
  Research output: Contribution to journal › Article › peer-review
• PublishedRenal transplant patients’ preference for the supply and delivery of immunosuppressants in Wales: A discrete choice experiment
  Hagemi, A., Plumpton, C. & Hughes, D., 2 Oct 2017, In: BMC Nephrology. 18, 305.
  Research output: Contribution to journal › Article › peer-review
• PublishedSocietal perspective on access to publicly subsidised medicines: A cross sectional survey of 3080 adults in Australia
  Chim, L., Salkeld, G., Kelly, P., Lipworth, W., Hughes, D. & Stockler, M., 1 Mar 2017, In: PLoS ONE.
  Research output: Contribution to journal › Article › peer-review
• PublishedSubcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica
  Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., Foster, N. E., Walsh, D. A., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S. & Wilkinson, C., 31 Oct 2017, In: Health Technology Assessment. 21, 60, p. 1-180 180 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedUse Of The Ims Core Diabetes Model (CDM) In A Long-Term Projected Health Economic Comparison Of CSII And MDI Treatments Of Type 1 Diabetes (T1D) In A Newly-Diagnosed Population Of Paediatric Patients
  Ridyard, C., Blair, J. & Hughes, D., 20 Oct 2017, In: Value in Health. 20, 9, p. A580
  Research output: Contribution to journal › Article › peer-review
• PublishedUsing Routinely Recorded Data in the UK to Assess Outcomes in a Randomised Controlled Trial: The Trials of Access
  Powell, G., Bonnett, L., Smith, C. T., Hughes, D., Williamson, P. & Marson, A., 23 Aug 2017, In: Trials. 18, 11 p., 389.
  Research output: Contribution to journal › Article › peer-review

2016

• Published2016 Prof. John Urquhart Obituary
  Breckenridge, A. & Hughes, D., Aug 2016, In: British Journal of Clinical Pharmacology. 82, 2, p. 573
  Research output: Contribution to journal › Letter › peer-review
• PublishedA randomised, patient-assessor blinded, sham-controlled trial of external noninvasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial
  Johnson, S., Goebel, A., Richey, R., Holmes, E. & Hughes, D., 6 Dec 2016, In: Trials. 17, 574.
  Research output: Contribution to journal › Article › peer-review
• PublishedA systematic review of economic evaluations of pharmacogenetic testing for prevention of adverse drug reactions
  Plumpton, C. O., Roberts, D., Pirmohamed, M. & Hughes, D. A., Aug 2016, In: Pharmacoeconomics. 34, 8, p. 771-793
  Research output: Contribution to journal › Article › peer-review
• PublishedA systematic review of patients' perspectives on the subcutaneous route of medication administration
  Ridyard, C., Dawoud, D. M., Tuersley, L. V. & Hughes, D., Aug 2016, In: Patient: Patient–Centered Outcomes Research. 9, 4, p. 281-292
  Research output: Contribution to journal › Article › peer-review
• PublishedCATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children
  Harron, K., Mok, Q., Dwan, K., Ridyard, C., Mott, T., Millar, M., Ramnarayan, P., Tibby, S. M., Muller-Pebody, B., Hughes, D., Gamble, C. & Gilbert, R. E., Mar 2016, In: Health Technology Assessment. 20, 18
  Research output: Contribution to journal › Article › peer-review
• PublishedConducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches
  Hughes, D., Charles, J. M., Dawoud, D. M., Edwards, R. T., Holmes, E. A., Jones, C. L., Parham, P., Plumpton, C., Ridyard, C. O., Lloyd-Williams, H., Wood, E. M. & Yeo, S., May 2016, In: Pharmacoeconomics. 34, 5, p. 447-461
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden
  Verhoef, T. I., Redekop, W. K., Langenskiold, S., Kamali, F., Wadelius, M., Burnside, G., Maitland-van der Zee, A. H., Hughes, D. & Pirmohamed, M., Oct 2016, In: The Pharmacogenomics Journal. 16, p. 478–484
  Research output: Contribution to journal › Article › peer-review
• PublishedGeneralisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England
  Harron, K., Mok, Q., Hughes, D., Muller-Pebody, B., Parslow, R., Ramnarayan, P. & Gilbert, R., 21 Mar 2016, In: PLoS ONE. 11, 3, p. e0151348
  Research output: Contribution to journal › Article › peer-review
• PublishedHealth Economics Analysis Plans: Where Are We Now?
  Thorn, J., Ridyard, C., Hughes, D., Wordsworth, S., Mihaylova, B., Noble, S. & Hollingworth, W., 3 Nov 2016, p. A397. 1 p.
  Research output: Contribution to conference › Poster › peer-review
• PublishedImpregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial
  Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., Ramnarayan, P., Tibby, S. M., Hughes, D. & Gamble, C. F., 23 Apr 2016, In: The Lancet. 387, 10029, p. 1732-1742
  Research output: Contribution to journal › Article › peer-review
• PublishedMultiple imputation of multiple multi-item scales when a full imputation model is infeasible
  Hughes, D., Plumpton, C. O., Morris, T., Hughes, D. A. & White, I. R., 26 Jan 2016, In: BMC Research Notes. 9, 45, p. 1-15
  Research output: Contribution to journal › Article › peer-review
• PublishedOpportunity costs and local health service spending decisions: a qualitative study from Wales
  Schaffer, S. K., Sussex, J., Hughes, D. & Devlin, N., 25 Mar 2016, In: BMC Health Services Research. 16, 103
  Research output: Contribution to journal › Article › peer-review
• PublishedProfitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study
  Hughes, D. & Poletti-Hughes, J., 21 Oct 2016, In: PLoS ONE. 11, 10, e0164681.
  Research output: Contribution to journal › Article › peer-review
• PublishedWhat influences persistence with medicines? A multinational discrete choice experiment of 2549 patients
  Holmes, E. A., Morrison, V. L. & Hughes, D., Aug 2016, In: British Journal of Clinical Pharmacology. 82, 2, p. 522-531
  Research output: Contribution to journal › Article › peer-review

2015

• PublishedAdherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria
  Lotsch, F., Auer-Hackenberg, L., Groger, M., Rehman, K., Morrison, V. L., Holmes, E. A., Parveen, S., Plumpton, C. O., Clyne, W., de Geest, S., Dobbels, F., Vrijens, B., Kardas, P., Hughes, D. & Ramharter, M., May 2015, In: Wiener klinische Wochenschrift. 127, 9-10, p. 379-384
  Research output: Contribution to journal › Article › peer-review
• PublishedClimate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios
  Hughes, D., Parham, P. E. & Hughes, D. A., 16 Feb 2015, In: Philosophical Transactions B: Biological Sciences. 370, 1665
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy
  Plumpton, C., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M. & Hughes, D., Apr 2015, In: Epilepsia.
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence
  Hughes, D., Plumpton, C. O., Brown, I., Reuber, M., Marson, A. G. & Hughes, D. A., 26 Mar 2015, In: Epilepsy and Behavior. 45, p. 180-186
  Research output: Contribution to journal › Article › peer-review
• PublishedEvaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions
  Hughes, D., Roberts, E., Dawoud, D. M., Hughes, D. A. & Cefai, C., 1 Oct 2015, In: International Journal of Pharmacy Practice. 23, 5, p. 333-339
  Research output: Contribution to journal › Article › peer-review
• PublishedIdentification Of Items For A Standardised Resource-Use Measure: Review Of Current Instruments
  Thorn, J. C., Ridyard, C., Riley, R., Brookes, S., Hughes, D., Wordsworth, S., Noble, S. & Hollingworth, W., Nov 2015.
  Research output: Contribution to conference › Paper › peer-review
• PublishedNICE recommendations: why no disinvestment recommendations to offset investment decisions?
  Hughes, D., Tuersley, L. V., Hughes, D. A., Wood, E. M. & Tuersley, L., 19 May 2015, In: BMJ. 350
  Research output: Contribution to journal › Article › peer-review
• PublishedPharmacogenetic testing prior to carbamazepine treatment of epilepsy: 1 patients’ and physicians’ preferences for testing and service delivery
  Powell, G., Holmes, E. A., Plumpton, C. O., Ring, A., Baker, G. A., Jacoby, A., Pirmohamed, M., Marson, A. G. & Hughes, D. A., 3 Jul 2015, In: British Journal of Clinical Pharmacology. 80, 5, p. 1149-1159
  Research output: Contribution to journal › Article › peer-review
• PublishedPredictors of Self-Reported Adherence to Antihypertensive Medicines: A Multinational, Cross-Sectional Survey
  Morrison, V. L., Holmes, E. A., Parveen, S., Plumpton, C. O., Clyne, W., De Geest, S., Dobbels, F., Vrijens, B., Kardas, P. & Hughes, D., Mar 2015, In: Value in Health. 18, 2, p. 206-216
  Research output: Contribution to journal › Article › peer-review
• PublishedRare Disease Terminology and Definitions—A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group
  Hughes, D., Richter, T., Nestler-Parr, S., Babela, R., Khan, Z. M., Tesoro, T., Molsen, E. & Hughes, D. A., 18 Aug 2015, In: Value in Health. 18, 6, p. 906-914
  Research output: Contribution to journal › Article › peer-review
• PublishedReview of resource-use measures in UK economic evaluations
  Ridyard, C. & Hughes, D., 2015, PSSRU Unit Costs of Health and Social Care 2015 . Curtis, L. & Burns, A. (eds.). University of Kent, Canterbury, p. 22-31 10 p.
  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• PublishedStudy protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections
  Blair, J., Gregory, J., Hughes, D., Ridyard, C., Gamble, C., McKay, A., Didi, M., Thornborough, K., Bedson, E., Awoyale, L., Cwiklinski, E. & Peak, M., 16 Apr 2015, In: Trials. 16, 163.
  Research output: Contribution to journal › Article › peer-review
• PublishedTaxonomy for methods of resource use measurement
  DIRUM Team, 23 Jan 2015, In: Health Economics. 24, 3, p. 372-378
  Research output: Contribution to journal › Letter › peer-review
• PublishedThe ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial
  Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., Bulbeck, H., Das, K., Farrell, M., Looby, S., Hickey, H., Preusser, M., Mallucci, C. L., Hughes, D., Gamble, C. & Weber, D. C., 14 Nov 2015, In: Trials. 16
  Research output: Contribution to journal › Article › peer-review
• Published‘Seizure First Aid Training’ for people with epilepsy who attend emergency departments, and their family and friends: study protocol for intervention development and a pilot randomised controlled trial
  Noble, A. J., Marson, A. G., Tudur-Smith, C., Morgan, M., Hughes, D., Goodacre, S. & Ridsdale, L., 24 Jul 2015, In: BMJ Open. 5, 7
  Research output: Contribution to journal › Article › peer-review

2014

• PublishedA randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial)
  Hughes, D., Ramanan, A., Dick, A. D., Benton, D., Compeyrot-Lacassagne, S., Dawoud, D., Hardwick, B., Hickey, H., Hughes, D. A., Jones, A., Woo, P., Edelsten, C., Beresford, M. W. & The SYCAMORE Trail Management Group, [. V., 9 Jan 2014, In: Trials. 15, 14
  Research output: Contribution to journal › Article › peer-review
• PublishedDoes Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity
  Hughes, D., Sutton, S., Kinmonth, A. L., Hardeman, W., Hughes, D. A., Boase, S., Prevost, T., Kellar, I., Graffy, J., Griffin, S. & Farmer, A., 1 Dec 2014, In: Annals of Behavioral Medicine. 48, 3, p. 293-299
  Research output: Contribution to journal › Article › peer-review
• PublishedFolate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation
  Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., Lewis, H., Lloyd, K., McCaddon, A., Moat, S., Pink, J., Pirmohamed, M., Roberts, S., Russell, I., Sylvestre, Y., Tranter, R., Whitaker, R., Wilkinson, C. & Williams, N., Jul 2014, In: Health Technology Assessment. 18, 48, p. 1-159
  Research output: Contribution to journal › Article › peer-review
• PublishedPredicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research
  Holmes, E. A., Morrison, V. L. & Hughes, D., 8 Dec 2014, In: Value in Health. 17, 8, p. 863-876
  Research output: Contribution to journal › Article › peer-review
• PublishedThe British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol
  Hughes, D., Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D. A., Blundell, M., Griffiths, M. J., Solomon, T. & Malluci, C. L., 3 Jan 2014, In: Trials. 15, 14
  Research output: Contribution to journal › Article › peer-review
• PublishedValuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population
  Hughes, D., Mulhern, B., Rowen, D., Snape, D., Jacoby, A., Marson, T., Hughes, D. A., Baker, G. & Brazier, J., 1 Jul 2014, In: Epilepsy and Behavior. 36, p. 12-17
  Research output: Contribution to journal › Article › peer-review

2013

• PublishedA Systematic Review of Patient Preferences for Subcutaneous Medications
  Ridyard, C., Dawoud, D. & Hughes, D., Nov 2013.
  Research output: Contribution to conference › Paper › peer-review
• PublishedAdherence and variability in warfarin dose requirements: assessment in a prospective cohort
  Hughes, D., Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M. & Williamson, P. R., 1 Jan 2013, In: Pharmacogenomics. 14, 2, p. 151-163
  Research output: Contribution to journal › Article › peer-review
• PublishedComparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation
  Hughes, D., Pink, J., Pirmohamed, M. & Hughes, D. A., 25 Apr 2013, In: Clinical Pharmacology and Therapeutics.
  Research output: Contribution to journal › Article › peer-review
• PublishedCost effectiveness of pharmacogenetic screening prior to initiation of carbamazepine treatment for epilepsy
  Plumpton, C. O., Yip, V., Alfirevic, A., Marson, A., Pirmohamed, M. & Hughes, D., Nov 2013, In: Value in Health. 16, 7, p. A624-A624
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-Effectiveness of Pharmacogenetics-Guided Warfarin Therapy vs. Alternative Anticoagulation in Atrial Fibrillation
  Hughes, D., Pink, J., Pirmohamed, M., Lane, S. & Hughes, D. A., 23 Sept 2013, In: Clinical Pharmacology and Therapeutics.
  Research output: Contribution to journal › Article › peer-review
• PublishedDecision-Makers’ Preferences for Approving New Medicines in Wales: A Discrete-Choice Experiment with Assessment of External Validity
  Hughes, D., Linley, W. G. & Hughes, D. A., 1 Apr 2013, In: Pharmacoeconomics. 31, 4, p. 345-355
  Research output: Contribution to journal › Article › peer-review
• PublishedIdentification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis
  Hughes, D., Holmes, E. A., Demonceau, J., Ruppar, T., Kristano, P., Hughes, A. D., Fargher, E., Przemyslaw, K., De Geest, S., Dobbels, F., Lewek, P., Urquhart, J. & Vrijens, B., 1 May 2013, In: Drugs. 73, 6, p. 545-562
  Research output: Contribution to journal › Article › peer-review
• PublishedImpact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group
  Hughes, D., Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A. & Grubisic, M., 1 Jul 2013, In: Value in Health. 16, 5, p. 863-871
  Research output: Contribution to journal › Article › peer-review
• PublishedInterventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group
  Hughes, D., Linck, P. G., Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F. H., Linck, P. & Cowell, W., 1 Dec 2013, In: Osteoporosis International. 24, 12, p. 2907-2918
  Research output: Contribution to journal › Article › peer-review
• PublishedNew advice on switching antiepileptic drugs might be a false economy
  Holmes, E. A., Plumpton, C. O., Hughes, D., Holmes, E., Plumpton, C., Duerden, M., Marson, T. & Hughes, D. A., 16 Dec 2013, In: British Medical Journal. 347
  Research output: Contribution to journal › Article › peer-review
• PublishedPharmacogenetic tests: the need for a level playing field
  Hughes, D., Pirmohamed, M. & Hughes, D. A., 1 Jan 2013, In: Nature Reviews Drug Discovery. 12, 3-4
  Research output: Contribution to journal › Article › peer-review
• PublishedResource-Use Measurement Based on Patient Recall: Issues and Challenges for Economic Evaluation
  Thorn, J. C., Coast, J., Cohen, D., Hollingworth, W., Knapp, M., Noble, S. M., Ridyard, C. H., Wordsworth, S. & Hughes, D., 1 Jun 2013, In: Applied Health Economics and Health Policy. 11, 3, p. 155-161
  Research output: Contribution to journal › Article › peer-review
• PublishedReview of the Use of Resource Use Instruments Based on Patient Recall in Relation to Other Methods of Cost Estimation
  Ridyard, C. & Hughes, D., Nov 2013.
  Research output: Contribution to conference › Paper › peer-review
• PublishedReview of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation
  Ridyard, C. & Hughes, D., Nov 2013.
  Research output: Contribution to conference › Paper › peer-review
• PublishedScreening log data can be used to inform protocol modifications, increasing patient recrutiment to a challanging clinical trial
  Blair, J., Awoyale, L., Thornborough, K., Peak, M., Didi, M., Bedson, E., Hughes, D., Ridyard, C., Tat, T. & Gregory, J., Nov 2013.
  Research output: Contribution to conference › Paper › peer-review
• PublishedSocietal views on NICE, cancer drugs fund and value-based pricing criteria for prioritising medicines: a cross-sectional survey of 4118 adults in Great Britain
  Hughes, D., Linley, W. G. & Hughes, D. A., 1 Aug 2013, In: Health Economics. 22, 8, p. 948-964
  Research output: Contribution to journal › Article › peer-review

2012

• PublishedA Risk–Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention
  Hughes, D., Guzauskas, G. F., Hughes, D. A., Bradley, S. M. & Veenstra, D. L., 28 Mar 2012, In: Clinical Pharmacology and Therapeutics.
  Research output: Contribution to journal › Article › peer-review
• PublishedA new taxonomy for describing and defining adherence to medications
  Holmes, E. A., Hughes, D., Morrison, V. L., Vrijens, B., De Geest, S., Hughes, D. A., Prezemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., Matyjaszczyk, M., Mshelia, C., Clyne, W., Aronson, J. K. & Urquhart, J., 1 May 2012, In: British Journal of Clinical Pharmacology. 73, 5, p. 691-705
  Research output: Contribution to journal › Article › peer-review
• PublishedAn agenda for UK clinical pharmacology Pharmacoeconomics
  Hughes, D. & Hughes, D. A., 1 Jun 2012, In: British Journal of Clinical Pharmacology. 73, 6, p. 968-972
  Research output: Contribution to journal › Article › peer-review
• PublishedAn explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes
  Hughes, D., Farmer, A., Hardeman, W., Hughes, D. A., Prevost, A. T., Kim, Y., Craven, A., Oke, J., Boase, S., Selwood, M., Kellar, I., Graffy, J., Griffin, S., Sutton, S. & Kinmonth, A. L., 5 Apr 2012, In: BMC Family Practice. 13, 30
  Research output: Contribution to journal › Article › peer-review
• PublishedChallenges in the Development and Reimbursement of Personalized Medicine—Payer and Manufacturer Perspectives and Implications for Health Economics and Outcomes Research: A Report of the ISPOR Personalized Medicine Special Interest Group
  Hughes, D., Faulkner, E., Annemans, L., Garrison, L., Helfand, M., Holtorf, A. P., Hornberger, J., Hughes, D. A., Li, T., Malone, D., Payne, K., Siebert, U., Towse, A., Veenstra, D. & Watkins, J., 1 Dec 2012, In: Value in Health. 15, 8, p. 1162-1171
  Research output: Contribution to journal › Article › peer-review
• PublishedCost–effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs
  Hughes, D., Verhof, T. I., Redekop, W. K., van Schie, R. M., Bayat, S., Daly, A. K., Geitona, M., Haschke-Becher, E., Hughes, D. A., Kamali, F., Levin, L. A., Manolopoulos, V. G., Pirmohamed, M., Siebert, U., Stingl, J. C., Wadelius, M., de Boer, A. & Maitland-van der Zee, A. H., 1 Sept 2012, In: Pharmacogenomics. 13, 12, p. 1405-1417
  Research output: Contribution to journal › Article › peer-review
• PublishedDefining rewardable innovation in drug therapy
  Hughes, D., Aronson, J. K., Ferner, R. E. & Hughes, D. A., 1 Apr 2012, In: Nature Reviews Drug Discovery. 11, p. 253-254
  Research output: Contribution to journal › Article › peer-review
• PublishedDevelopment of a Database of Instruments for Resource-Use Measurement: Purpose, Feasibility, and Design
  DIRUM Team, 1 Jul 2012, In: Value in Health. 15, 5, p. 650-655
  Research output: Contribution to journal › Article › peer-review
• PublishedMechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.
  Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.
  Research output: Contribution to journal › Article › peer-review
• PublishedReimbursement Decisions of the All Wales Medicines Strategy Group
  Hughes, D., Linley, W. G. & Hughes, D. A., 1 Sept 2012, In: PharmoEconomics. 30, 9, p. 779-794
  Research output: Contribution to journal › Article › peer-review
• PublishedThe Population Pharmacokinetics of R and S-Warfarin: Effect of Genetic and Clinical Factors
  Hughes, D., Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., Daly, A. K., Aarons, L., Ogungbenro, K., Kamali, F., Hughes, D. A. & Pirmohamed, M., 1 Jan 2012, In: British Journal of Clinical Pharmacology. 73, 1, p. 66-76
  Research output: Contribution to journal › Article › peer-review
• PublishedThe development of a QALY measure for epilepsy: NEWQOL-6D
  Hughes, D., Mulhern, B., Rowen, D., Jacoby, A., Marson, T., Snape, D., Hughes, D. A., Latimer, N., Baker, G. A. & Brazier, J. E., 1 May 2012, In: Epilepsy and Behavior. 24, 1, p. 36-43
  Research output: Contribution to journal › Article › peer-review

2011

• PublishedDabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses
  Hughes, D., Pink, J., Lane, S., Pirmohamed, M. & Hughes D.A., [. V., 31 Oct 2011, In: British Medical Journal. 343, p. 1-14
  Research output: Contribution to journal › Article › peer-review
• PublishedHTAs and rare diseases: How to assess their cost-effectiveness
  Hughes, D., Phillips, C. J. & Hughes, D. A., 1 Nov 2011, In: Pharmaceuticals Policy and Law. 13, 3-4, p. 161-165
  Research output: Contribution to journal › Article › peer-review
• PublishedInvolving colleagues can be challenging
  Fargher , E. & Hughes, D., 2 Apr 2011, In: Pharmaceutical Journal. 286, p. 404
  Research output: Contribution to journal › Letter › peer-review
• PublishedValue-Based Pricing: Incentive for Innovation or Zero Net Benefit?
  Hughes, D. & Hughes, D. A., 1 Sept 2011, In: Pharmacoeconomics. 29, 9, p. 731-735
  Research output: Contribution to journal › Article › peer-review

2010

• PublishedA systematic review of cost–effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives
  Hughes, D., Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., de Boer, A., Maitland-van der Zee, A. H., Barallon, R., Briz, M., Daly, A., Haschke-Becher, E., Kamali, F., Kirchheiner, J., Manolopoulos, V. G., Pirmohamed, M., Rosendaal, F. R., van Schie, R. M. & Wadelius, M., 1 Jul 2010, In: Pharmacogenomics. 11, 7, p. 989-1002
  Research output: Contribution to journal › Article › peer-review
• PublishedAbolition of prescription charges in Wales: the impact on medicines use in those who used to pay
  Hughes, D., Groves, S., Cohen, D., Alam, M. F., Dunstan, F. D., Routledge, P. A., Hughes, D. A. & Myles, S., 1 Dec 2010, In: International Journal of Pharmacy Practice. 18, 6, p. 332-340
  Research output: Contribution to journal › Article › peer-review
• PublishedAbolition of prescription copayments in Wales: an observational study on dispensing rates.
  Hughes, D., Cohen, D., Alam, M. F., Dunstan, F. D., Myles, S., Hughes, D. A. & Routledge, P. A., 1 Aug 2010, In: Value in Health. 13, 5, p. 675-680
  Research output: Contribution to journal › Article › peer-review
• PublishedBiosimilars: Evidential standards for health technology assessment.
  Hughes, D. & Hughes, D. A., 1 Mar 2010, In: Clinical Pharmacology and Therapeutics. 87, 3, p. 257-261
  Research output: Contribution to journal › Article › peer-review
• PublishedEnhancing methodical approaches for studying bilingualism in healthcare communication: report of a trial feasibility study.
  Roberts, G. W., Hughes, D., Roberts, G., Owen, H., Hughes, L., Whitaker, R., Deuchar, M., Hughes, D. A., Llewelyn, S., John, S., Irvine, F., Owen, B. & Rowlands, A., 1 Jan 2010.
  Research output: Contribution to conference › Paper
• PublishedFrom NCE to NICE: the role of pharmacoeconomics
  Hughes, D. & Hughes, D. A., 1 Sept 2010, In: British Journal of Clinical Pharmacology. 70, 3, p. 317-319
  Research output: Contribution to journal › Article › peer-review
• PublishedGeneric and therapeutic substitutions in the UK: are they a good thing?
  Hughes, D., Duerden, M. G. & Hughes, D. A., 1 Sept 2010, In: British Journal of Clinical Pharmacology. 70, 3, p. 335-341
  Research output: Contribution to journal › Article › peer-review
• PublishedIs exercise effective in promoting mental well-being in older age? A systematic review.
  Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T. & Woods, R. T., 1 Aug 2010, In: Aging and Mental Health. 14, 6, p. 652-669
  Research output: Contribution to journal › Article › peer-review
• PublishedMethods for the collection of resource use data within clinical trials: A systematic review of studies funded by the UK Health Technology Assessment Program
  Ridyard, C. H. & Hughes, D., 1 Dec 2010, In: Value in Health. 13, 8, p. 867-872
  Research output: Contribution to journal › Article › peer-review
• PublishedNICE and new: appraising innovation.
  Hughes, D., Ferner, R. E., Hughes, D. A. & Aronson, J. K., 5 Jan 2010, In: British Medical Journal. 340, p. b5493
  Research output: Contribution to journal › Article › peer-review
• PublishedNew drugs for old: disinvestment and NICE.
  Hughes, D., Hughes, D. A. & Ferner, R. E., 25 Feb 2010, In: British Medical Journal. 340, p. c572
  Research output: Contribution to journal › Article › peer-review
• PublishedThe problem of orphan drugs
  Hughes, D., Ferner, R. E. & Hughes, D. A., 16 Nov 2010, In: British Medical Journal. 341, p. 335-341
  Research output: Contribution to journal › Article › peer-review

2009

• PublishedA Framework for Planning and Critiquing Medication Compliance and Persistence Research Using Prospective Study Designs.
  Hughes, D., Gwadry-Sridhar, F. H., Manias, E., Zhang, Y., Roy, A., Yu-Isenberg, K., Hughes, D. A. & Nichol, M. B., 1 Feb 2009, In: Clinical Therapeutics. 31, 2, p. 421-435
  Research output: Contribution to journal › Article › peer-review
• PublishedA systematic review and empirical analysis of the relation between dose and duration of drug action.
  Hughes, D., Hughes, D. A. & Aronson, J. K., 1 Jan 2009, p. TP40.
  Research output: Contribution to conference › Paper
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Ambrisentan (Volibris) for pulmonary arterial hypertension.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2009, 2009 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Anidulafungin (Ecalta) for the treatment of invasive candidiasis in adult non-neutropenic patients.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2009, 2009 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Maraviroc (Celsentri) for treatment-experienced adults infected only with CCR5-tropic HIV-1.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2009, 2009 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Tacrolimus (Advagraf) for the prophylaxis of transplant rejection in adult kidney or liver allograft recipients and the treatment of allograft rejection resistant to treatment with other immunosuppressive medicinal products in adult patients.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2009, 2009 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAssessment, Determinants & Economics of Medication Compliance & Persistence Forum.
  Hughes, D., Hughes, D. A., Gwadry-Sridhar, F. & Manias, E., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedBiosimilars: Evidential standards for health technology assessment.
  Hughes, D. & Hughes, D. A., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedBiosimilars: Evidential standards for health technology assessment.
  Hughes, D. & Hughes, D. A., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedComparisons between the medication possession ratio (MPR) and gaps measures of medication compliance: are we selling ourselves short by relying on the MPR?
  Hughes, D., Nichol, M., Manias, E., Hughes, D. A. & Schabert, V. F., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedCost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis.
  Sorensen, S. V., Baker, T., Fleurence, R., Dixon, J., Roberts, C., Haider, S. & Hughes, D., 1 Aug 2009, In: International Journal of Tuberculosis and Lung Disease. 13, 8, p. 945-954
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data.
  Hughes, D., Bodger, K., Kikuchi, T. & Hughes, D. A., 1 Aug 2009, In: Alimentary Pharmacology and Therapeutics. 30, 3, p. 265-274
  Research output: Contribution to journal › Article › peer-review
• PublishedCosts of Medication Nonadherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the Literature.
  Hughes, D., Salas, M., Hughes, D. A., Zuluaga, A., Vardeva, K. & Lebmeier, M., 1 Sept 2009, In: Value in Health. 12, 6, p. 915-922
  Research output: Contribution to journal › Article › peer-review
• PublishedDrug evaluation and pharmocoeconomics.
  Hughes, D., Krska, J., Hughes, D. A., Winfield, A. J. (Editor), Rees, J. A. (Editor) & Smith, I. (Editor), 1 Jan 2009, Pharmaceutical Practice: 4th Edition.. 2009 ed. Churchill Livingstone, p. 185-198
  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• PublishedEconomic evaluation of infliximab and adalimumab for Crohn's disease.
  Hughes, D., Hughes, D. A., Bodger, K. & Kikuchi, T., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedEngaging with the MRC Methodology Hubs – NWHTMR.
  Hughes, D. & Hughes, D. A., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedEstimating Drug Costs in Economic Evaluations in Ireland and the UK: An Analysis of Practice and Research Recommendations.
  Hughes, D., Hughes, D. A., Tilson, L. & Drummond, M. F., 1 May 2009, In: Pharmacoeconomics. 27, 8, p. 635-643
  Research output: Contribution to journal › Article › peer-review
• PublishedFollow-up of cancer in primary care versus secondary care: systematic review
  Lewis, R. A., Neal, R. D., Williams, N. H., France, B., Hendry, M., Russell, D., Hughes, D. A., Russell, I., Stuart, N. S. A., Weller, D. & Wilkinson, C., 1 Jul 2009, In: British Journal of General Practice. 59, 564, p. e234-e247
  Research output: Contribution to journal › Article › peer-review
• PublishedGenetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.
  Hughes, D., Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., Van Eker, D., Stevens, L., Hawkins, K., Toh, C. H., Kamali, F., Daly, A. K., Fitzmaurice, D., Coffey, A., Williamson, P. R., Park, B. K., Deloukas, P. & Pirmohamed, M., 1 Oct 2009, In: Pharmacogenetics and Genomics. 19, 10, p. 800-812
  Research output: Contribution to journal › Article › peer-review
• PublishedImpact of pharmacogenetics on the costs of managing adverse events with warfarin: A prospective analysis.
  Hughes, D., Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A. & Pirmohamed, M., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedImpact of the abolition of the prescription charge in Wales.
  Hughes, D., Hughes, D. A., Alam, M. F., Cohen, D., Dunstan, F., Groves, S. & Routledge, P., 1 Jan 2009, p. O41.
  Research output: Contribution to conference › Paper
• PublishedImpact of the abolition of the prescription charge in Wales.
  Hughes, D., Hughes, D. A., Alam, M. F., Cohen, D., Dunstan, F., Groves, S. & Routledge, P., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedImpact of the abolition of the prescription charge in Wales.
  Hughes, D., Hughes, D. A., Alam, M. F., Cohen, D., Dunstan, F., Groves, S. & Routledge, P., 1 Jan 2009.
  Research output: Contribution to conference › Paper
• PublishedMeasurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
  Hughes, D., Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., Hughes, D. A., Molyneux, M. E., Ward, S. A., Winstanley, P. A. & Lalloo, D. G., 26 Aug 2009, In: Malaria Journal. 8, p. 204
  Research output: Contribution to journal › Article › peer-review
• PublishedNurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review
  Lewis, R., Neal, R. D., Williams, N. H., France, B., Wilkinson, C. E., Hendry, M., Russell, D., Russell, I., Hughes, D., Stuart, N. S. & Weller, D., 1 Apr 2009, In: Journal of Advanced Nursing. 65, 4, p. 706-723
  Research output: Contribution to journal › Article › peer-review
• PublishedPatients' and healthcare professionals' views of cancer follow-up: systematic review
  Lewis, R., Neal, R. D., Hendry, M., France, B., Williams, N. H., Russell, D., Hughes, D. A., Russell, I., Stuart, N. S. A., Weller, D. & Wilkinson, C., Jul 2009, In: British Journal of General Practice. 59, 564, p. e248-e259
  Research output: Contribution to journal › Article › peer-review
• PublishedPharmacoeconomics: principles and relevance to the activities of drug and therapeutics committees.
  Hughes, D., Hughes, D. A. & Reynolds, D. J., 1 Oct 2009, In: Clinical Medicine. 9, 5, p. 490-492
  Research output: Contribution to journal › Article › peer-review
• PublishedThe economics of evergreening.
  Hughes, D. & Hughes, D. A., 1 Jan 2009.
  Research output: Contribution to conference › Paper

2008

• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Abacavir 600mg/lamivudine 300mg (Kivexa) in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus infection in adults and adolescents from 12 years of age.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Alemtuzumab (MabCampath) for the treatment of patients with B-cell chronic lymphocytic leukaemia for whom fludarabine combination chemotherapy is not appropriate.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Atazanavir (Reyataz) in treatment-experienced patients.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Atazanavir (Reyataz) in treatment-naïve patients.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Buprenorphine/naloxone (Suboxone) as substitution treatment for opioid dependence.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Deferasirox (Exjade) for the treatment of chronic iron overload due to blood transfusions.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Docetaxel (Taxotere) for locally advanced squamous cell carcinoma of the head and neck.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Epoetin delta (Dynepo)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Fondaparinux Sodium (Arixtra®) for STEMI.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Fondaparinux Sodium (Arixtra®) for UA/NSTEMI.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Icatibant (Firazyr) for symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults (with C1-esterase-inhibitor deficiency).
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Lenalidomide (Revlimid) for multiple myeloma.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Pegfilgrastim (Neulasta) for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with cytotoxic chemotherapy for malignancy.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Raltegravir (Isentress) in combination with other antiretroviral medicinal products for the treatment of human immunodeficiency virus (HIV-1) infection in treatment-experienced adult patients with evidence of HIV-1 replication despite ongoing antiretroviral therapy.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Rufinamide (Inovelon) for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS).
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Stiripentol (Diacomit) for use in conjunction with clobazam and valproate in patients with severe myoclonic epilepsy in infancy.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Tenofovir disoproxil fumarate (Viread) for the treatment of hepatitis B.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Teriparatide (Forsteo) for the treatment of osteoporosis in men at increased risk of fracture.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Topotecan (Hycamtin®) for Small Cell Lung Carcinoma.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Trabectedin (Yondelis) for advanced soft tissue sarcoma.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Ziconotide (Prialt) for the intrathecal treatment of severe, chronic pain.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedCharitable contributions to funding cancer services for children and young people in England and Wales
  Hughes, D., Linck, P., Tunnage, B., Hughes, D. A. & Edwards, R. T., 1 Jan 2008, In: Journal of Child Health Care. 12, 2, p. 156-168
  Research output: Contribution to journal › Article › peer-review
• PublishedChiral chromatography: Costs of chiral switching.
  Hughes, D. & Hughes, D. A., 1 Jan 2008, In: Pharmaceutical Journal. 281, p. 213
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness analysis of infliximab and adalimumab for Crohn's disease.
  Hughes, D., Hughes, D. A., Bodger, K. & Kikuchi, T., 1 Apr 2008.
  Research output: Contribution to conference › Paper
• PublishedCost-effectiveness analysis of infliximab and adalimumab for Crohn's disease.
  Hughes, D., Hughes, D. A., Bodger, K. & Kikuchi, T., 1 Apr 2008.
  Research output: Contribution to conference › Paper
• PublishedCost-effectiveness considerations in pharmacogenetics.
  Hughes, D. & Hughes, D. A., 1 Jan 2008.
  Research output: Contribution to conference › Paper
• PublishedCosts of non-compliance to antipsychotic medications among patients with schizophrenia.
  Hughes, D., Hughes, D. A., Salas, M., Zuluaga, A., Cowell, W., Lebmeier, M., Vardeva, K., Pisu, M. & Shinogle, J., 1 May 2008.
  Research output: Contribution to conference › Paper
• PublishedDevelopment of an economic model to evaluate the cost-effectiveness of rival therapies for treating Crohn’s disease.
  Hughes, D., Kikuchi, T., Bodger, K. & Hughes, D. A., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedEconomic considerations for market access of new health technologies: A case study of pharmacogenetic testing
  Hughes, D. & Hughes, D. A., 1 Feb 2008.
  Research output: Contribution to conference › Paper
• PublishedEconomic considerations for pharmacogenetic testing
  Hughes, D. & Hughes, D. A., 1 Jun 2008.
  Research output: Contribution to conference › Paper
• PublishedEffects of the abolition of prescription charges in Wales: A preliminary analysis
  Hughes, D., Hughes, D. A., Alam, F., Cohen, D., Dunstan, F. & Routledge, P., 1 Apr 2008.
  Research output: Contribution to conference › Paper
• PublishedEffects of the abolition of prescription charges in Wales: a preliminary analysis.
  Hughes, D., Cohen, D., Alam, M. F., Hughes, D. A., Dunstan, F. & Routledge, P., 1 Jan 2008, In: International Journal of Pharmacy Practice. 16, Supplement 1, p. A39
  Research output: Contribution to journal › Article › peer-review
• PublishedEstimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens
  Hughes, D. & Hughes, D. A., 1 Dec 2008, In: British Journal of Clinical Pharmacology. 65, 6, p. 871-878
  Research output: Contribution to journal › Article › peer-review
• PublishedFrom efficacy to cost-effectiveness: Impact of patient compliance
  Hughes, D. & Hughes, D. A., 1 Feb 2008.
  Research output: Contribution to conference › Paper
• PublishedImpact of the abolition of the prescription charge in Wales
  Hughes, D. & Hughes, D. A., 1 Nov 2008.
  Research output: Contribution to conference › Paper
• PublishedIntegrating compliance and persistence in health economics models
  Hughes, D. & Hughes, D. A., 1 Jan 2008.
  Research output: Contribution to conference › Paper
• PublishedInvestigating factors influencing user choices to visit either general practioners or community pharmacists in the management of minor ailments - piloting a discrete choice experiment.
  Hughes, D., Hughes, D. A., Myles, S., Longo, M. & Lisles, C., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedInvestigating factors influencing user choices to visit either general practitioners or community pharmacists in the management of minor ailments – piloting a discrete choice experiment
  Hughes, D., Hughes, D. A., Myles, S., Longo, M. & Lisles, C., 1 Mar 2008
  Research output: Non-textual form › Web publication/site
• PublishedMedicines concordance and game theory.
  Hughes, D. & Hughes, D. A., 1 Oct 2008, In: British Journal of Clinical Pharmacology. 66, 4, p. 577
  Research output: Contribution to journal › Article › peer-review
• PublishedMethodological Issues in the literature on costs of non-compliance in chronic diseases.
  Hughes, D., Salas, M., Zuluaga, A., Hughes, D. A., Cowell, W., Lebmeier, M., Vardeva, K., Pisu, M. & Shinogle, J., 1 Nov 2008, In: Value in Health. 11, 6, p. A571-A572
  Research output: Contribution to journal › Article › peer-review
• PublishedMethodological issues in the literature on costs of non-compliance in chronic diseases
  Hughes, D., Salas, M., Zuluaga, A., Hughes, D. A., Cowell, W., Lebmeie, M., Vardeva, K., Pisu, M. & Shinogle, J., 1 Nov 2008.
  Research output: Contribution to conference › Paper
• PublishedPublic health interventions to promote well-being in people aged 65 and over: systematic review of effectiveness and cost-effectiveness.
  Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T., Morgan, R., Woods, R. T., Burholt, V., Edwards, R. T., Reeves, C. & Yeo, S. T., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedPublic health interventions to promote well-being in people aged 65 and over: systematic review of effectiveness and cost-effectiveness: Evidence Tables.
  Hughes, D., Linck, P. G., Windle, G., Linck, P., Morgan, R., Hughes, D. A., Burholt, V., Reeves, C., Yeo, S. T., Woods, R. T., Edwards, R. T. & Russell, I. T., 1 Jan 2008, 2008 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedStatistical comments are unfounded.
  Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Mar 2008, In: Value in Health. 11, 2, p. 346
  Research output: Contribution to journal › Article › peer-review
• PublishedThe all wales medicines strategy group: assessments and appraisals
  Hughes, D. & Hughes, D. A., 1 Nov 2008.
  Research output: Contribution to conference › Paper
• PublishedThe cost-effectiveness of biological therapies for Crohn's disease: Markov cohort analyses incorporating UK patient-level cost data
  Hughes, D., Bodger, K., Kikuchi, T. & Hughes, D. A., 1 Mar 2008.
  Research output: Contribution to conference › Paper
• PublishedThe cost-effectiveness of biological therapies for Crohn's disease: markov cohot analyses incorporating UK patient-level cost data
  Hughes, D., Hughes, D. A., Bodger, K. & Kikuchi, T., 1 May 2008.
  Research output: Contribution to conference › Paper
• PublishedUnderstanding medication compliance and persistence from an economics perspective
  Hughes, D., Elliot, R. A., Shinogle, J. A., Peele, P., Bhosle, M. & Hughes, D. A., 1 Jan 2008, In: Value in Health. 11, 4, p. 600-610
  Research output: Contribution to journal › Article › peer-review

2007

• PublishedA Global Survey of Antibiotic Leftovers in the Outpatient Setting.
  Hughes, D., Kardas, P., Pechere, J. C., Hughes, D. A. & Cornaglia, G., 1 Dec 2007, In: International Journal of Antimicrobial Agents. 30, 6, p. 530-536
  Research output: Contribution to journal › Article › peer-review
• PublishedA parenting programme for children at risk of developing conduct disorder: A cost-effectiveness analysis
  Hughes, D., Edwards, R. T., Ceilleachair, A., Bywater, T., Hughes, D. A. & Hutchings, J., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedA prototype agent-based model of antimalarial drug compliance
  Hughes, D., McKean, J., Rahlf, S., Shorter, H., Barnish, G., Paton, R., McBurney, P., Hughes, D. A. & Hastings, I., 1 Aug 2007.
  Research output: Contribution to conference › Paper
• PublishedAWMSG criteria for appraising new medicines.
  Hughes, D. & Hughes, D. A., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAdherence with HAART: pharmacoeconomic considerations
  Hughes, D. & Hughes, D. A., 1 Jun 2007.
  Research output: Contribution to conference › Paper
• PublishedAdverse drug reactions in economic evaluations
  Hughes, D. & Hughes, D. A., 1 Mar 2007.
  Research output: Contribution to conference › Paper
• PublishedAdverse drug reactions in economic evaluations
  Hughes, D. & Hughes, D. A., 1 Jul 2007.
  Research output: Contribution to conference › Paper
• PublishedAdverse drug reactions in economic evaluations
  Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Value in Health. 10, 3, p. A109
  Research output: Contribution to journal › Article › peer-review
• PublishedAdverse drug reactions: analysis by regulatory authorities and by economists
  Hughes, D. & Hughes, D. A., 1 Apr 2007.
  Research output: Contribution to conference › Paper
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report - Emtricitabine/tenofovir DF (Truvada)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Clofarabine (Evoltra)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Co-careldopa intestinal gel (Duodopa).
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Darunavir (Prezista)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Dasatinib (Sprycel®) Chronic, accelerated or blast phase CML.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Dasatinib (Sprycel®) Lymphoid blast CML and PH+ ALL.
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Dexrazoxane (Savene)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Emtricitabine (Emtriva)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Idursulfase (Elaprase)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Parathyroid hormone (Preotact)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Appraisal Report – Tipranavir (Aptivus).
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAll Wales Medicines Strategy Group Final Assessment Report – Agalsidase alfa (Replagal)
  Hughes, D., Hughes, D. A. & All Wales Strategy Group., [. V., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedAssessing the association between compliance and therapeutic failure for antiretroviral drugs in HIV positive patients
  Hughes, D., 1 Mar 2007.
  Research output: Contribution to conference › Paper
• PublishedAssessing the association between compliance and therapeutic failure for antiretroviral drugs in HIV positive patients
  Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Value in Health. 10, 3, p. A171
  Research output: Contribution to journal › Article › peer-review
• PublishedAssessing the association between compliance and therapeutic failure for antiretroviral drugs in HIV positive patients
  Hughes, D. & Hughes, D. A., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedBiological agents for the management of Crohn's disease in adults: A systematic review, meta-analysis and multiples treatment comparison
  Hughes, D., Hughes, D. A., Kikuchi, T. & Bodger, K., 1 Jan 2007, In: Value in Health. 10, 3, p. A147
  Research output: Contribution to journal › Article › peer-review
• PublishedBiological agents for the management of Crohn's disease in adults: a systematic review, meta-analysis and multiple treatment comparison
  Hughes, D., Hughes, D. A., Kikuchi, T. & Bodger, K., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedCost of non-compliance and non-persistence with medications for diabetes mellitus
  Hughes, D., Salas, M., Hughes, D. A., Lebmeier, M. & Vardeva, K., 1 Aug 2007.
  Research output: Contribution to conference › Paper
• PublishedCurrent assessment of risk-benefit by regulators: Is it time to introduce decision analyses?
  Hughes, D., Hughes, D. A., Pirmohamed, M. & Bayoumi, A., 1 Aug 2007.
  Research output: Contribution to conference › Paper
• PublishedCurrent assessment of risk-benefit by regulators: is it time to introduce decision analyses?
  Hughes, D., Hughes, D. A., Bayoumi, A. M. & Pirmohamed, M., 1 Aug 2007, In: Clinical Pharmacology and Therapeutics. 82, 2, p. 123-127
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomic evaluation of steroid injections (methylprednisolone) in the treatment of Morton's neuroma: patient-blind randomised trial
  Hughes, D., Thomson, C., Beggs, I., Martin, D., McCaldin, D., Russell, D., Edwards, R. T., Hughes, D. A., Yeo, S. T., Russell, I. T. & Gibson, T. N., 1 Mar 2007.
  Research output: Contribution to conference › Paper
• PublishedFactors influencing user choices to visit either general practitioners or community pharmacists for minor ailments – a discrete choice experiment
  Hughes, D., Hughes, D. A., Myles, S., Longo, M., Lisles, C. & Hood, K., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedFactors influencing user choices to visit either general practitioners or community pharmacists for minor ailments – a discrete choice experiment
  Hughes, D., Hughes, D. A., Myles, S., Longo, M., Lisles, C. & Hood, K., 1 Jan 2007, In: Value in Health. 10, 3, p. A23
  Research output: Contribution to journal › Article › peer-review
• PublishedFalls and hip-fractures: A cost-effectiveness analysis of risk assessment and interventions for community-dwelling older people
  Hughes, D., Gwynne, D., Hughes, D. A. & Edwards, R. T., 1 Mar 2007.
  Research output: Contribution to conference › Paper
• PublishedFeasibility, validity and reliability of the Welsh EQ-5D health status questionnaire
  Hughes, D. & Hughes, D. A., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedFeasibility, validity and reliability of the Welsh EQ-5D health status questionnaire
  Hughes, D., 1 Mar 2007.
  Research output: Contribution to conference › Paper
• PublishedFeasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire.
  Hughes, D. & Hughes, D. A., 1 Oct 2007, In: Quality of Life Research. 16, 8, p. 1419-1423
  Research output: Contribution to journal › Article › peer-review
• PublishedFeasibility, validity, and reliability of the Welsh version of the EQ-5D health status questionnaire
  Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Value in Health. 10, 3, p. A189
  Research output: Contribution to journal › Article › peer-review
• PublishedFolate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial.
  Russell, I. T., Slegg, G. P., Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Moat, S., Pirmohamed, M., Slegg, G., Tranter, R., Whitaker, R., Wilkinson, C. & Russell, I., 15 Nov 2007, In: BMC Psychiatry. 7, 1, p. 65
  Research output: Contribution to journal › Article › peer-review
• PublishedFollow-up of cancer patients in primary care versus secondary care: systematic review.
  Hughes, D., Lewis, R., Neal, R., Williams, N., France, B., Wilkinson, C., Hendry, M., Russell, D., Hughes, D. A., Russell, I. T., Stuart, N. S. & Weller, D., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedImpact of the abolition of prescription charges in Wales: a multi-level modelling approach with application to time series dispensed rate data
  Hughes, D., Alam, F., Myles, S., Hughes, D. A., Dunstan, F., Routledge, P. & Cohen, D., 1 Sept 2007.
  Research output: Contribution to conference › Paper
• PublishedInterventions that enhance medication compliance and persistence: Theoretical grounding, and economic assessment
  Hughes, D., Hughes, D. A., Gwadry Sridhar, F., Elliott, R. & Cowell, W., 1 Oct 2007.
  Research output: Contribution to conference › Paper
• PublishedMethods for integrating medication compliance and persistence in pharmacoeconomic evaluations.
  Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Nov 2007, In: Value in Health. 10, 6, p. 498-509
  Research output: Contribution to journal › Article › peer-review
• PublishedNon-compliance with antibiotic therapy for acute community infections: A global survey.
  Hughes, D., Pechere, J. C., Hughes, D. A., Kardas, P. & Cornaglia, G., 1 Mar 2007, In: International Journal of Antimicrobial Agents. 29, 3, p. 245-253
  Research output: Contribution to journal › Article › peer-review
• PublishedOrphan drug treatments: economic considerations
  Hughes, D. & Hughes, D. A., 1 Nov 2007.
  Research output: Contribution to conference › Paper
• PublishedParenting programme for parents of children at risk of developing conduct disorder: cost effectiveness analysis.
  Bywater, T. J., Hutchings, J. M., Hughes, D., Edwards, R. T., Ceilleachair, A., Bywater, T., Hughes, D. A. & Hutchings, J., 31 Mar 2007, In: British Medical Journal. 334, 7595, p. 682-685
  Research output: Contribution to journal › Article › peer-review
• PublishedPharmacoeconomic evaluations in Ireland, Scotland and Wales: A Celtic perspective on pharmaceutical assessment
  Hughes, D., Hughes, D. A., Drummond, M., Tolley, K. & Ryan, M., 1 Oct 2007.
  Research output: Contribution to conference › Paper
• PublishedPolicy on ultra-orphan drugs.
  Hughes, D. & Hughes, D. A., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedPopulation pharmacokinetics of warfarin: Intermin analysis of the Liverpool pharmacogenetic prospective cohort study
  Hughes, D., Matthews, I., Aarons, L., Al-Zubiedi, S., Hatch, E., Lane, S., Williamson, P., Kamali, F., Hughes, D. A. & Pirmohamed, M., 1 Nov 2007.
  Research output: Contribution to conference › Paper
• PublishedPublic health interventions to promote mental well-being in people aged 65 and over: systematic review of effectiveness and cost-effectiveness.
  Hughes, D., Windle, G., Hughes, D. A., Linck, P., Morgan, R., Burholt, V., Edwards, R. T., Reeves, C., Yeo, S. T., Woods, R. T. & Russell, I. T., 1 Jan 2007, 2007 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedPublic meetings of the NICE appraisals committee
  Hughes, D. & Hughes, D. A., 1 Dec 2007.
  Research output: Contribution to conference › Paper
• PublishedQuantitative risk-benefit analysis
  Hughes, D. & Hughes, D. A., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedSystematic review of follow-up of cancer in primary care verses secondary care: findings for breast and lung cancer
  Hughes, D., Lewis, R., Neal, R. D., France, B., Williams, N. H., Wilkinson, C., Russell, I. T., Russell, D., Hughes, D. A., Stuart, N. S. & Weller, D., 1 Mar 2007.
  Research output: Contribution to conference › Paper
• PublishedThe assessment, determinants & economics of medication compliance & persistence
  Hughes, D., Hughes, D. A., Gwadry Sridhar, F. & Elliott, R., 1 Oct 2007.
  Research output: Contribution to conference › Paper
• PublishedThe effect of compliance upon clinical effectiveness of chlorproguanil-dapsone (CD) and artemether-lumefantrine (AL) when compared to sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated falcipaum malaria in Malawi - a randomised controlled trial
  Hughes, D., Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., Zijlstra, E., Hughes D.A., [. V., Molyneux M.E.*, [. V., Ward, S. A., Winstanley, P. A. & Lalloo, D. G., 1 Nov 2007.
  Research output: Contribution to conference › Paper
• PublishedThe pharmacokinetic profile of Warfarn: a systematic review
  Hughes, D., Al-Zubiedi S.*, [. V., Hughes D.A., [. V. & Pirmohamed, M., 1 Dec 2007.
  Research output: Contribution to conference › Paper
• PublishedWarfarin pharmacogenetics: Economic considerations.
  Hughes, D., Hughes, D. A. & Pirmohamed, M., 1 Jan 2007, In: Pharmacoeconomics. 25, 11, p. 899-902
  Research output: Contribution to journal › Article › peer-review
• PublishedWhat determines which interventions improve compliance, and do they improve health outcomes in a cost-effective manner?
  Hughes, D., Hughes, D. A., LaFleur.*, [. V., Salas, M. & Shinogle, J., 1 May 2007.
  Research output: Contribution to conference › Paper
• PublishedWhen drugs don't work - Economic assessment of enhancing compliance with interventions supported by electronic monitoring devices.
  Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Pharmacoeconomics. 25, 8, p. 621-635
  Research output: Contribution to journal › Article › peer-review

2006

• PublishedBack to basics: what is the relationship between dose and duration of drug action?
  Hughes, D. & Hughes, D. A., 1 May 2006.
  Research output: Contribution to conference › Paper
• PublishedBeyond registration: measuring the public health potential of new treatments for Malaria in Africa.
  Hughes, D., Lang, T., Hughes, D. A., Kanyok, T., Kengeya-Kayondo, J., Marsh, V., Haaland, A., Pirmohamed, M. & Winstanley, P., 1 Jan 2006, In: Lancet Infectious Diseases. 6, 1, p. 46-52
  Research output: Contribution to journal › Article › peer-review
• PublishedClinical and econnomic importance of completion of therapy in the treatment of LRTIs
  Hughes, D. & Hughes, D. A., 1 Sept 2006.
  Research output: Contribution to conference › Paper
• PublishedEliciting patients' preferences using a discrete choice experiment questionnaire: the role played by qualitative data in questionnaire design
  Hughes, D., Longo, M., Hughes, D. A., Myles, S. & Lisles, C., 1 Mar 2006.
  Research output: Contribution to conference › Paper
• PublishedHealth and economic outcomes: Why compliance matters
  Hughes, D. & Hughes, D. A., 1 Apr 2006.
  Research output: Contribution to conference › Paper
• PublishedHealth economic aspects of patient non-compliance
  Hughes, D., Hughes, D. A., Davies, M. (Editor) & Kermani, F. (Editor), 1 Jan 2006, Patient Compliance: Sweetening the Pill. 2006 ed. Gower Publishing, p. 23-40
  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• PublishedImproving Outcomes for People with Brain and Other CNS Tumours: Analysis of the Potential Economic Impact of the Guidance.
  Hughes, D., Linck, P., Priedane, E., Hughes, D. A. & Edwards, R. T., 1 Jan 2006, 2006 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedImproving Outcomes for People with Sarcoma: Analysis of the Potential Economic Impact of the Guidance.
  Hughes, D., Linck, P., Hughes, D. A. & Edwards, R. T., 1 Jan 2006, 2006 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedImproving Outcomes for People with Skin Tumours including Melanoma: Analysis of the Potential Economic Impact of the Guidance.
  Hughes, D., Linck, P., Hughes, D. A. & Edwards, R. T., 21 Feb 2006, Unknown.
  Research output: Book/Report › Commissioned report
• PublishedInvestigating factors influencing user choices to visit either general practitioners or community pharmacists in the management of minor ailments
  Hughes, D. & Hughes, D. A., 1 May 2006.
  Research output: Contribution to conference › Paper
• PublishedInvestigating factors influencing user choices to visit either general practitioners or community pharmacists in the management of minor ailments - piloting a discrete choice experiment
  Hughes, D., Myles, S., Hughes, D. A., Longo, M. & Lisles, C., 1 Jun 2006.
  Research output: Contribution to conference › Paper
• PublishedLess is more: Medicines that require less frequent administration improve adherence, but are they better?
  Hughes, D. & Hughes, D. A., 1 Jan 2006, In: Pharmacoeconomics. 24, 3, p. 211-213
  Research output: Contribution to journal › Article › peer-review
• PublishedOrphan drugs revisited: author's response.
  Hughes, D. & Hughes, D. A., 1 May 2006, In: Quarterly Journal of Medicine. 99, 5, p. 350-351
  Research output: Contribution to journal › Article › peer-review
• PublishedPhyschiatrist prescribing preferences and attitudes toward promotion
  Hughes, D., Menkes, D., Davies, R. & Hughes, D. A., 1 Apr 2006.
  Research output: Contribution to conference › Paper
• PublishedPopulation pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.
  Simpson, J. A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., Edwards, G., Watkins, W. A. & Ward, S., 1 Mar 2006, In: British Journal of Clinical Pharmacology. 61, 3, p. 289-300
  Research output: Contribution to journal › Article › peer-review
• PublishedPrescription fee exemption research study
  Hughes, D., Myles, S., Hughes, D. A., Routledge, P. & Wales, D. F., 1 Jun 2006.
  Research output: Contribution to conference › Paper
• PublishedPublic funding of drugs for orphan diseases
  Hughes, D. & Hughes, D. A., 1 Jan 2006.
  Research output: Contribution to conference › Paper
• PublishedRationing of drugs for rare diseases
  Hughes, D. & Hughes, D. A., 1 Apr 2006.
  Research output: Contribution to conference › Paper
• PublishedRationing of drugs for rare diseases.
  Hughes, D. & Hughes, D. A., 1 Jan 2006, In: Pharmacoeconomics. 24, 4, p. 315-316
  Research output: Contribution to journal › Article › peer-review
• PublishedUltra-long acting pharmaceuticals: Do they result in better outcomes, and at an acceptable cost?
  Hughes, D. & Hughes, D. A., 1 Nov 2006.
  Research output: Contribution to conference › Paper

2005

• PublishedCisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: Pharmacoeconomic considerations.
  Hughes, D. & Hughes, D. A., 1 Jul 2005, In: European Journal of Cancer. 41, 11, p. 1655
  Research output: Contribution to journal › Article › peer-review
• PublishedCost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease.
  Hughes, D., Hughes, D. A., Marchetti, M. & Colombo, G., 1 Feb 2005, In: Expert Review of Pharmacoeconomics and Outcomes Research. 5, 1, p. 29-38
  Research output: Contribution to journal › Article › peer-review
• PublishedDrugs for exceptionally rare diseases: do they deserve special status for funding?
  Hughes, D., Tunnage, B. & Yeo, S. T., 1 Nov 2005, In: QJM - An International Journal of Medicine. 98, 11, p. 829-836
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease.
  Hughes, D., Hughes, D. A., Bodger, K., Bytzer, P., De Herdt, D. & Dubois, D., 1 Jan 2005, In: Pharmacoeconomics. 23, 10, p. 1031-1041
  Research output: Contribution to journal › Article › peer-review
• PublishedEmpirical analysis of the relationship between dose and duration of drug action
  Hughes, D. & Hughes, D. A., 1 Jun 2005.
  Research output: Contribution to conference › Paper
• PublishedImproving Outcomes in Children and Young People with Cancer: Analysis of the Potential Economic Impact of the Guidance.
  Hughes, D., Linck, P., Tunnage, B., Hughes, D. A. & Edwards, R. T., 1 Jan 2005, 2005 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedIncorporating measures of compliance and persistence in pharmacoeconomic evaluations
  Hughes, D., Hughes, D. A. & Cowell, W., 1 Nov 2005.
  Research output: Contribution to conference › Paper
• PublishedInternationalisation of cost-effectiveness model for on-demand use of proton pump inhibitors - Sweden.
  Hughes, D. & Hughes, D. A., 1 Jan 2005, 2005 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedPharmacokinetics, patient compliance and pharmaeconomics
  Hughes, D. & Hughes, D. A., 1 Jun 2005.
  Research output: Contribution to conference › Paper
• PublishedPublic funding of drugs for orphan diseases
  Hughes, D. & Hughes, D. A., 11 Nov 2005, In: Value in Health. 8, 6, p. A192
  Research output: Contribution to journal › Article › peer-review
• PublishedPublic funding of drugs for orphan diseases
  Hughes, D. & Hughes, D. A., 1 Nov 2005.
  Research output: Contribution to conference › Paper
• PublishedPublic funding of drugs for orphan diseases
  Hughes, D. & Hughes, D. A., 1 Nov 2005.
  Research output: Contribution to conference › Paper
• PublishedPublic funding of drugs for orphan diseases
  Hughes, D. & Hughes, D. A., 1 Jul 2005.
  Research output: Contribution to conference › Paper
• PublishedTrends and influences on use of antidiabetic drugs in England, 1992-2003.
  Walley, T., Hughes, D. & Kendall, H., 1 Nov 2005, In: Pharmacoepidemiology and Drug Safety. 14, 11, p. 769-773
  Research output: Contribution to journal › Article › peer-review
• PublishedWelsh Health Economics Network (WHEN): Scoping Report.
  Hughes, D., Farr, A., O Ceilleachair, A., Cohen, D., Hughes, D. A. & Phillips, C., 1 Jan 2005, 2005 ed. Unknown.
  Research output: Book/Report › Commissioned report

2004

• PublishedA single centre open phase IV study to evaluate the safety and tolerability of chlorproguanil-dapsone when dosed by defined height bands
  Hughes, D., Makanga, M., Winstanley, P. & Hughes, D. A., 1 Nov 2004.
  Research output: Contribution to conference › Paper
• PublishedApproaches to pharmacoeconomic analysis
  Hughes, D., Hughes, D. A., Walley, T. (Editor), Haycox, A. (Editor), Boland, A. (Editor) & Breckenridge, A. (Editor), 1 Jan 2004, Pharmacoeconomics. 2004 ed. Adis International, p. 101-126
  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• PublishedClinical Pharmacology: Special safety considerations in drug development and pharmacovigilance.
  Hughes, D., Atuah, K. N., Hughes, D. A. & Pirmohamed, M., 1 Jan 2004, In: Drug Safety. 27, 8, p. 535-554
  Research output: Contribution to journal › Article › peer-review
• PublishedCost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease
  Hughes, D. & Hughes, D. A., 1 Nov 2004, In: Value in Health. 7, 6, p. 753
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity
  Hughes, D., Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K. & Pirmohamed, M., 1 Jun 2004, In: Pharmacogenetics. 14, 6, p. 335-342
  Research output: Contribution to journal › Article › peer-review
• PublishedCost-effectiveness analysis of extended-release formulations of oxybutynin and tolterodine for the management of urge incontinence.
  Hughes, D., Hughes, D. A. & Dubois, D., 1 Jan 2004, In: Pharmacoeconomics. 22, 16, p. 1047-1059
  Research output: Contribution to journal › Article › peer-review
• PublishedEconomic evaluation of on-demand maintenance therapy with proton pump inhibitors in patients with symptomatic gastroesophageal reflux disease - a Monte-Carlo analysis for Italy
  Hughes, D., Hughes, D. A., Marchetti, M. & Colombo, G., 1 Oct 2004.
  Research output: Contribution to conference › Paper
• PublishedFrom efficacy to effectiveness and cost-effectiveness: modelling possibilities
  Hughes, D. & Hughes, D. A., 1 Nov 2004.
  Research output: Contribution to conference › Paper
• PublishedHLA-B*5701 and abacavir hypersensitivity - Reply.
  Hughes, D., Hughes, D. A., Park, B. K. & Pirmohamed, M., 1 Nov 2004, In: Pharmacogenetics. 14, 11, p. 784
  Research output: Contribution to journal › Article › peer-review
• PublishedInternationalisation of cost-effectiveness model for on-demand use of proton pump inhibitors - Belgium.
  Hughes, D. & Hughes, D. A., 1 Jan 2004, 2004 ed. Unknown.
  Research output: Book/Report › Commissioned report
• PublishedIntroduction to pharmaeconomics
  Hughes, D. & Hughes, D. A., 1 Jul 2004.
  Research output: Contribution to conference › Paper
• PublishedModelling in health economics
  Hughes, D., Hughes, D. A., Walley, T. (Editor), Haycox, A. (Editor), Boland, A. (Editor) & Breckenridge, A. (Editor), 1 Jan 2004, Pharmacoeconomics. 2004 ed. Adis International, p. 141-154
  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• PublishedPatient compliance and persistence with prescribed medication: Measurement and health economic impact
  Hughes, D., Koncz, T., Hughes, D. A., Cleemput, I. & Annemans, L., 1 May 2004.
  Research output: Contribution to conference › Paper
• PublishedPharmacoeconomic models that incorporate non-compliance
  Hughes, D. & Hughes, D. A., 1 Jul 2004.
  Research output: Contribution to conference › Paper
• PublishedPharmacoeconomics appraisals by the all Wales medicines strategy group
  Hughes, D. & Hughes, D. A., 1 Jul 2004.
  Research output: Contribution to conference › Paper
• PublishedPharmacoeconomics in Wales: functions of the all Wales medicines strategy group
  Hughes, D. & Hughes, D. A., 1 Apr 2004.
  Research output: Contribution to conference › Paper
• PublishedPharmacoeconomics of pharmacogenetic testing: azathioprine
  Hughes, D., McAllister, R. & Hughes, D. A., 1 Apr 2004.
  Research output: Contribution to conference › Paper
• PublishedThe difference between effectiveness and efficacy of antimalarial drugs in Kenya.
  Hughes, D., Amin, A. A., Hughes, D. A., Marsh, V., Abuya, T. O., Kokwaro, G. O., Winstanley, P. A., Ochala, S. A. & Snow, R. W., 1 Sept 2004, In: Tropical Medicine and International Health. 9, 9, p. 967-974
  Research output: Contribution to journal › Article › peer-review
• PublishedThe future challenges
  Hughes, D., Hughes, D. A., Walley, T. (Editor), Haycox, A. (Editor), Boland, A. (Editor) & Breckenridge, A. (Editor), 1 Jan 2004, Pharmacoeconomics. 2004 ed. Adis International, p. 167-174
  Research output: Chapter in Book/Report/Conference proceeding › Chapter