Daniel Hill-McManus

Email: d.mcmanus@bangor.ac.uk
Phone: +44(0)1248 388745


Dan joined CHEME in 2015 to undertake a PhD on the development and application of linked pharmacometric and pharmacoeconomic modelling to support decision making in clinical drug development. The three year PhD studentship is funded by the Medical Research Council’s Network of Hubs for Trials Methodology Research (HTMR) and is supervised by Professor Dyfrig Hughes (Bangor) and Dr Steven Lane (Liverpool). This project also involves an industry collaboration with Pharmacometrics in Pfizer. The aim of the PhD project is to demonstrate ways in which early pharmacoeconomic modelling may improve methods for strategic, clinical and pricing decisions during phase II/III drug development. The work has so far focussed on a case study of urate lowering therapies for the treatment of gout.

Dan completed a BSc in theoretical physics at Edinburgh University in 2009, and afterwards spent a short time working in the private sector as a risk analyst conducting safety studies of oil and gas installations. He was a research associate for over four year at the School of Health and Related Research at The University of Sheffield where he was a member of the Sheffield Alcohol Research Group, working on many projects in the area of alcohol and public health. These included studies of the potential impact of pricing policies for alcohol for the English and Scottish governments and working with Public Health England on the design of specialist services to treat people with alcohol dependence.


Hill-McManus D, Marshall S, Soto E, Lane S & Hughes D. Impact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model. Value in Health. 2018. ACCEPTED.

Hill-McManus D, Soto E, Marshall S, Lane S, Hughes. Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. Br J Clin Pharmacol. 2018; 84(1):142-152.


Carroll CKaltenthaler EHill-McManus DScope AHolmes MRice SRose MTappenden PWoolacott N. The Type and Impact of Evidence Review Group Exploratory Analyses in the NICE Single Technology Appraisal Process. Value in Health. 2017. Volume 20 , Issue 6, 785 – 791

Kaltenthaler E, Carroll C, Hill-McManus D, et al. Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process. PharmacoEconomics Open. 2017; 1(2):99-108.


Kaltenthaler ECarroll CHill-McManus DScope AHolmes MRice SRose MTappenden PWoolacott N. The use of exploratory analyses within the National Institute for Health and Care Excellence single technology appraisal process: an evaluation and qualitative analysis. Health Technol Assess. 2016; Apr;20(26):1-48.


Brennan A, Meng Y, Holmes J, Hill-McManus D, Meier PS. Potential benefits of minimum unit pricing for alcohol versus a ban on below cost selling in England 2014: modelling study. BMJ. 2014 Sep 30; 349:g5452

Holmes J, Meng Y, Meier PS, Brennan A, Angus C, Campbell-Burton A, Guo Y, Hill-McManus D, Purshouse RC. Effects of minimum unit pricing for alcohol on different income and socioeconomic groups: a modelling study. Lancet. 2014 May 10; 383(9929):1655-64

Ally AK, Meng Y, Chakraborty R, Dobson PW, Seaton JS, Holmes J, Angus C, Guo Y, Hill-McManus D, Brennan A, Meier PS. Alcohol tax pass-through across the product and price range: do retailers treat cheap alcohol differently? Addiction. 2014 Dec; 109(12):1994-2002

Meng Y, Brennan A, Purshouse R, Hill-McManus D, Angus C, Holmes J, Meier PS. Estimation of own and cross price elasticities of alcohol demand in the UK—A pseudo-panel approach using the Living Costs and Food Survey 2001-2009. J Health Econ. 2014 Mar; 34:96-103


Meier PS, Meng Y, Holmes J, Baumberg B, Purshouse R, Hill-McManus D, Brennan A. Adjusting for unrecorded consumption in survey and per capita sales data: quantification of impact on gender- and age-specific alcohol-attributable fractions for oral and pharyngeal cancers in Great Britain. Alcohol Alcohol. 2013 Mar-Apr; 48(2):241-9

Hill-McManus D, Angus C, Meng Y, Holmes J, Brennan A, Sylvia Meier P. Estimation of usual occasion-based individual drinking patterns using diary survey data. Drug Alcohol Depend. 2014 Jan 1; 134:136-43

Meng Y, Holmes J, Hill-McManus D, Brennan A, Meier PS. Trend analysis and modelling of gender-specific age, period and birth cohort effects on alcohol abstention and consumption level for drinkers in Great Britain using the General Lifestyle Survey 1984-2009. Addiction. 2014 Feb; 109(2):206-15


Hill-McManus D, Alan Brennan, Tim Stockwell, Norman Giesbrecht, Gerald Thomas, Jinhui Zhao, Gina Martin and Ashley Wettlaufer. Model-based appraisal of alcohol minimum pricing in Ontario and British Columbia: A Canadian adaptation of the Sheffield Alcohol Policy Model Version 2. December, 2012