Giovanna Culeddu


Giovanna is a Research Officer in Pharmacoeconomics at the Centre for Health Economics and Medicine Evaluation with a background in research methods and statistics. Previous to this post Giovanna worked as a researcher for Manchester City Council. She holds a MSc in Research Methods and Statistics from the University of Manchester and a MA degree in International Development: poverty, conflict and reconstruction from the University of Manchester. She is a trained quantitative researcher, with a particular focus on modelling large dataset to conduct statistical analysis by applying multi-level models and social network analysis.

Giovanna joined CHEME in 2015 and is currently working on several projects:

  • The use of Ferrous Iron salts in primary care in the UK (IHAT). This is a retrospective cross sectional study which will provide the health economics of iron treatment in the UK.
  • The British Antibiotic & Silver Impregnated Catheters for ventriculoperitoneal Shunts (BASICS). BASICS is a three-arm, double-blind multi-centre randomised controlled trial which will compare three ventriculoperitoneal shunts in patients with hydrocephalus.
  • Radiation versus Observation following surgical resection of Atypical Meningioma (the ROAM trial). ROAM is a two-arm, multicentre European randomised controlled trial for patients who have undergone surgical resection of grade II meningioma.
  • A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost Effectiveness of Adalimumab in Combination with MethOtRExate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis (SYCAMORE). SYCAMORE is a double blind, multicentre randomised controlled trial for patients with juvenile idiopathic arthritis associated uveitis.

Giovanna is undertaking a PhD in Pharmacoeconomics as a staff candidate. Her thesis will explore the applicability of different statistical methods (frequentist approach versus Bayesian) for trial based cost effectiveness analyses. Her PhD is funded by MRC (Medical Research Council) and is supervised by Professor Dyfrig Hughes (Bangor University) and Prof Nicky Welton (University of Bristol).


Mallucci, C.L. ; Jenkinson, M.D. ; Conroy, Elizabeth J. ; Hartley, John C. ; Brown, Michaela ; Dalton, Joanne ; Kearns, Tom ; Moitt, Tracey ; Griffiths, Michael J. ; Culeddu, Giovanna ; Solomon, Tom ; Hughes, Dyfrig ; Gamble, Carol. / Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multi-centre, single-blinded, randomised trial and economic evaluation. In: The Lancet. 2019.

Athimalaipet V Ramanan, Andrew D Dick, Ashley P Jones, Dyfrig A Hughes, Andrew McKay, Anna Rosala-Hallas, Paula R Williamson, Ben Hardwick, Helen Hickey, Naomi Rainford, Graeme Hickey, Ruwanthi Kolamunnage-Dona, Giovanna Culeddu, Catrin Plumpton, Eifiona Wood, Sandrine Compeyrot-Lacassagne, Patricia Woo, Clive Edelsten and Michael W Beresford on behalf of the SYCAMORE Study Group. Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT. Health Technology Assessment Volume: 23, Issue: 15, Published in April 2019

Dyfrig A Hughes, Giovanna Culeddu, Catrin Plumpton, Eifiona Wood, Andrew D Dick, Michael W Beresford, Athimalaipet V Ramanan. Letter to the Editor. Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis: Authors’ reply. Ophthalmology. 2019; 126:415-424.

Hughes, D., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot-Lacassagne, S., Hardwick, B., Hickey, H., Woo, P., Beresford, M. W. & Ramanan, A. V. Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis.  16 Oct 2018, In : Ophthalmology.

Michael D. Jenkinson, Damien C. Weber, Brian J. Haylock, Frances C. Sherratt, Bridget Young, Michael Weller, Helen Bulbeck, Giovanna Culeddu, Dyfrig A. Hughes, Alice Brain, Kumar Das, Matthias Preusser, Priya Francis, and Carrol Gamble. Letter to the Editor. Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma. Journal of Neurosurgery 2018, 1418 

Culeddu, Giovanna; Hughes, Dyfrig; Welton, Nicky. Comparison of regression methods for the cost effectiveness analysis of clinical trials with a small population size : the SYCAMORE and FolATED trials. /  2017. Poster session presented at 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials, Liverpool, United Kingdom.