Professor Dyfrig Hughes


Dyfrig graduated in pharmacy at Cardiff University before undertaking a PhD in cardiovascular pharmacology at the University of Liverpool. He subsequently trained in health economics, and is currently Professor of Pharmacoeconomics and co-director of the Centre for Health Economics and Medicines Evaluation at Bangor University. He is also academic lead for Pharmacy at the Betsi Cadwaladr University Health Board, and is honorary professor at the Department of Molecular and Clinical Pharmacology, University of Liverpool. He has led the pharmacoeconomic activities of the All Wales Therapeutics and Toxicology Centre, contributing to over 200 substantive Health Technology Assessment reports. He was inaugural president of the European Society for Patient Adherence, Compliance and Persistence (ESPACOMP) and was elected fellow of: the Learned Society of Wales, the British Pharmacological Society, and the Faculty of the Royal Pharmaceutical Society. His main research activities, which have led to over 120 publications, concern pharmaceutical economics and policy, health technology assessment and medication adherence. He is an editorial board member of the journals PharmacoEconomics and Clinical Pharmacology & Therapeutics.


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Currently funded projects:

AWTTC - Pharmacoeconomic assessment of new medicines in Wales
BASICS - British Antibiotic and Silver Impregnated Catheters for ventriculoperitoneal Shunts
CARiAD - CARer-ADministration of as-needed sub-cutaneous medication for breakthrough symptoms in home-based dying patients: a UK study
CASTLE - Changing Agendas on Sleep, Treatment and Learning in Childhood Epilepsy
CF START - The cystic fibrosis anti-staphylococcal antibiotic prophylaxis trial; a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF
COPD/Asthma - Health economic analysis of the adoption of all Wales prescribing guidelines for asthma and COPD
CRMO - Bayesian prior elicitation meeting for a planned randomised controlled trial of adalimumab versus pamidronate in chronic recurrent multifocal osteomyelitis
EMERGE - ESPACOMP Medication Adherence Reporting Guidelines
EN-PENS - A randomised patient-assessor blinded sham controlled trial of external non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury
i4i-HLA - A biomarker panel to predict, diagnose and prevent HLA-mediated serious adverse drug reactions
INTEGRATE - Fully integrated, real-time detection, diagnosis and control of community diarrhoeal disease clusters and outbreaks
IHAT - Health economics of the use of ferrous iron salts in primary care in the UK
PHW - Molecular Diagnostics Project
NWHTMR - North West Hub in Trials Methodological Research
MYPAN - An open label randomised controlled trial of mycophenolate mofetil versus cyclophosphamide for the induction of remission of childhood polyarteritis nodosa
NERVES - Comparison of effectiveness of transforaminal epidural steroid injection (TFESI) and surgical microdiscectomy for chronic sciatica secondary to a prolapsed intervertebral disc: study protocol for a randomised controlled trial
Opt-Life - Optimising quality of living throughout the course of a progressively disabling neurological condition
PACIFICO - Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for Older patients: a phase III comparison of R-CVP versus R-FC
Pancreatitis - Phase IIb, randomised, double-blind, placebo-controlled, multi-centre trial of infliximab with transcriptomic biomarker and mechanism evaluation in patients with acute pancreatitis
PETRaA - Phase 3 evaluation of PET-guided, Response-Adapted therapy in patients with previously untreated, high tumour burden follicular lymphoma
RDS - North West Research Design Service
RIAltO - A Randomised Investigation of Alternative Ofatumumab-containing regimens in less fit patients with CLL
ROAM - Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial
SAFE - Seizure first Aid training For Epilepsy’ for people with epilepsy who attend emergency departments, and their family and friends: Intervention development and pilot
SANAD2 - A pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs
SCIPI - SubCutaneous Insulin: Pumps or Injections?
SUMMIT-D - Supporting people with type 2 diabetes in effective use of their medicine through a system comprising mobile health technology integrated with clinical care
SYCAMORE - Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost Effectiveness of Adalimumab in Combination with Subcutaneous Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis

(updated 27th September 2016)